Barahona D, Adlerstein I, Donoso J, Mercado F
Departamento de Imagenología, Facultad de Medicina, Clínica Alemana-Universidad del Desarrollo, Vitacura, Santiago, Chile.
Departamento de Imagenología, Facultad de Medicina, Clínica Alemana-Universidad del Desarrollo, Vitacura, Santiago, Chile.
Radiologia (Engl Ed). 2020 Dec 24. doi: 10.1016/j.rx.2020.10.008.
Neurolymphomatosis (NL) is the infiltration of cranial nerves or nerves and roots from the peripheral nervous system by lymphoma, usually by B-cell non-Hodgkin's lymphoma. It is uncommon as initial presentation of the disease and can lead to extremely heterogeneous clinical manifestations. We report the case of a 72-year old male who presented with numbness of the right hand, progressive weakness in both lower limbs and weight loss. 18F-FDG PET/CT showed bilateral hypermetabolic adrenal masses, gastric ulcer, small hypermetabolic adenopathies, multiple focal bone marrow uptake and intense uptake in both sciatic nerves and right median nerve. A node and gastric biopsy confirmed diffuse large-B-cell lymphoma, activated B cell type, with posterior resolution of peripheral nerves uptake after beginning chemotherapy.
神经淋巴瘤（NL）是指淋巴瘤浸润颅神经或外周神经系统的神经及神经根，通常为B细胞非霍奇金淋巴瘤。它作为疾病的初始表现并不常见，可导致极为多样的临床表现。我们报告一例72岁男性病例，该患者表现为右手麻木、双下肢进行性无力及体重减轻。18F-FDG PET/CT显示双侧肾上腺代谢增高肿块、胃溃疡、小的代谢增高淋巴结、多处局灶性骨髓摄取以及双侧坐骨神经和右侧正中神经摄取增强。淋巴结及胃活检证实为弥漫性大B细胞淋巴瘤，活化B细胞型，化疗开始后外周神经摄取消失。
