皮肤类胡萝卜素状况可作为中老年人心血管疾病风险评估的潜在替代标志物。

Skin carotenoids status as a potential surrogate marker for cardiovascular disease risk determination in middle-aged and older adults.

机构信息

Department of Food Science & Technology, Faculty of Science, National University of Singapore, Singapore.

Saw Swee Hock School of Public Health, National University of Singapore, Singapore.

出版信息

Nutr Metab Cardiovasc Dis. 2021 Feb 8;31(2):592-601. doi: 10.1016/j.numecd.2020.10.016. Epub 2020 Oct 26.

DOI:10.1016/j.numecd.2020.10.016

PMID:33358716

Abstract

BACKGROUND AND AIMS

Upon consumption, carotenoids, which may attenuate cardiovascular disease (CVD) risk, diffuse from the blood and accumulate in the skin. This study aimed to assess the associations between dietary, plasma, and skin carotenoids with CVD risk indicators and to examine the mediational role of plasma carotenoids in the relationship between skin carotenoids status (SCS) and CVD risk.

METHODS AND RESULTS

Dietary, plasma, and skin carotenoids were assessed in a cross-sectional study from a community in Singapore (n = 103) aged 50 to 75 y. Multiple linear regression and binary logistics regression models were used to examine the associations between the carotenoids status with classical CVD risk factors and composite CVD risk indicators. After controlling for covariates, SCS and plasma carotenoids were inversely associated with systolic blood pressure (skin: P < 0.001; plasma: P < 0.05) and diastolic blood pressure (skin: P < 0.001; plasma: P < 0.005). Additionally, each increment of 1000 in SCS was associated with an odds ratio of 0.924 (P < 0.01) for metabolic syndrome diagnosis and 0.945 (P < 0.05) for moderate to high CVD risk classification. Associations between SCS and composite CVD risk indicators were null when adjusted for the corresponding plasma carotenoids, indicating complete mediation. Dietary carotenoids, however, showed no relationship with the CVD risk indicators.

CONCLUSION

Carotenoids bioavailability may be important for cardiovascular protection. SCS, driven by the corresponding plasma carotenoids, could be a potential noninvasive surrogate marker for CVD risk determination in middle-aged and older adults.

CLINICAL TRIAL REGISTRATION

NCT03554954, https://clinicaltrials.gov/.

TRIAL REGISTRATION DATE

13 June 2018.

摘要

背景与目的

食用后，类胡萝卜素可能会降低心血管疾病 (CVD) 的风险，从血液中扩散并在皮肤中积累。本研究旨在评估饮食、血浆和皮肤类胡萝卜素与 CVD 风险指标的相关性，并研究血浆类胡萝卜素在皮肤类胡萝卜素状态 (SCS) 与 CVD 风险之间的关系中的中介作用。

方法和结果

在新加坡社区进行的一项横断面研究中评估了饮食、血浆和皮肤类胡萝卜素（n = 103），年龄在 50 至 75 岁之间。使用多元线性回归和二元逻辑回归模型来检查类胡萝卜素状态与经典 CVD 风险因素和复合 CVD 风险指标之间的关系。在控制了协变量后，SCS 和血浆类胡萝卜素与收缩压（皮肤：P < 0.001；血浆：P < 0.05）和舒张压（皮肤：P < 0.001；血浆：P < 0.005）呈负相关。此外，SCS 每增加 1000，代谢综合征诊断的比值比为 0.924（P < 0.01），中度至高度 CVD 风险分类的比值比为 0.945（P < 0.05）。当调整相应的血浆类胡萝卜素时，SCS 与复合 CVD 风险指标之间的关联为零，表明完全中介。然而，饮食类胡萝卜素与 CVD 风险指标之间没有关系。