Gulati A K
Department of Anatomy, Medical College of Georgia, Augusta.
J Neurosurg. 1988 Jan;68(1):117-23. doi: 10.3171/jns.1988.68.1.0117.
Nerve grafts composed of basal lamina scaffolds and lacking viable Schwann cells have recently been shown to be effective in supporting axonal regeneration. As only short grafts were used in those studies, the present investigation was conducted to evaluate the ability of long acellular basal lamina nerve grafts and equivalent cellular grafts to support axonal regeneration for nerve gap repair. Cellular grafts consisted of nerve segments that had degenerated in situ for 4 weeks. Acellular grafting material consisted of similar segments that were repeatedly frozen and thawed to kill all cells prior to grafting. The results show that host axons can regenerate through the entire 4-cm length of cellular grafts but not through acellular basal lamina grafts. However, in the acellular grafts numerous axons were seen in the proximal 2-cm region. It is concluded that basal lamina grafts possess limited ability to support axonal regeneration. As in cellular grafts, viable Schwann cells appear to be important for regeneration to occur over longer distances.
最近研究表明，由基底层支架构成且缺乏存活雪旺细胞的神经移植物在支持轴突再生方面是有效的。由于那些研究中仅使用了短移植物，因此进行了本研究以评估长的去细胞基底层神经移植物和等效的细胞移植物支持轴突再生以修复神经间隙的能力。细胞移植物由原位退变4周的神经节段组成。去细胞移植材料由相似的节段组成，这些节段在移植前反复冻融以杀死所有细胞。结果显示，宿主轴突可通过细胞移植物的整个4厘米长度进行再生，但不能通过去细胞基底层移植物再生。然而，在去细胞移植物的近端2厘米区域可见大量轴突。得出的结论是，基底层移植物支持轴突再生的能力有限。与细胞移植物一样，存活的雪旺细胞对于更长距离的再生似乎很重要。
