在体外胃肠道模型下，受藻酸盐黏度影响的包封生物活性物质的释放。
Release of encapsulated bioactives influenced by alginate viscosity under in-vitro gastrointestinal model.
机构信息
Centre for Marine Bioproducts Development, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia 5042, Australia.
Flinders Institute for Nanoscale Science and Technology, College of Science and Engineering, Flinders University, Bedford Park, South Australia 5042, Australia.
出版信息
Int J Biol Macromol. 2021 Feb 15;170:540-548. doi: 10.1016/j.ijbiomac.2020.12.143. Epub 2021 Jan 4.
The physicochemical properties of alginate can affect the release profile of encapsulated bioactives, but this is poorly understood. The influence of alginate viscosity (low- A1, medium- A2 and high- A3) and molecular weight (kDa) on the release of encapsulated bioactives (seaweed and spirulina powder) was investigated in an in-vitro gastrointestinal (GSI) model. Beads encapsulated with A2 at 1% (w/v) have overall higher release of bioactives (protein, phlorotannins and antioxidants) but A3 at 0.5% (w/v) was able to release and absorb similar amount of bioactives with ~10% difference with A2. The relative release of protein, phlorotannins and antioxidant was 96%, 111% and 43% respectively from A2 in gastric digestion. In contrast, protein (165%) and phlorotannins (234%) release was highest from A3 in intestinal phase. These results establish the importance of physicochemical properties of the encapsulating matrix on water retention capacity and their interaction with bioactive material to release into the system.
海藻酸盐的物理化学性质会影响包封生物活性物质的释放情况，但目前对此了解甚少。本研究采用体外胃肠道（GSI）模型，考察了海藻酸盐黏度（低 A1、中 A2 和高 A3）和分子量（kDa）对包封生物活性物质（海藻和螺旋藻粉）释放的影响。浓度为 1%（w/v）的 A2 包埋的微球总体上具有更高的生物活性物质（蛋白质、岩藻黄质和抗氧化剂）释放率，但浓度为 0.5%（w/v）的 A3 能够释放和吸收与 A2 相似量的生物活性物质，差异约为 10%。在胃消化过程中，A2 中蛋白质、岩藻黄质和抗氧化剂的相对释放率分别为 96%、111%和 43%。相比之下，A3 在肠相时蛋白质（165%）和岩藻黄质（234%）的释放率最高。这些结果确立了包埋基质的物理化学性质对保水能力的重要性及其与生物活性物质相互作用释放到系统中的重要性。
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