Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Canada; Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China.
Neuroimage. 2021 Feb 15;227:117672. doi: 10.1016/j.neuroimage.2020.117672. Epub 2020 Dec 24.
Despite decades of research, our understanding of functional brain development throughout childhood and adolescence remains limited due to the challenges posed by certain neuroimaging modalities. Recently, there has been a growing interest in using functional near-infrared spectroscopy (fNIRS) to elucidate the neural basis of cognitive and socioemotional development and identify the factors shaping these types of development. This article, focusing on the fNIRS methods, presents an up-to-date systematic review of fNIRS studies addressing the effects of age and other factors on brain functions in children and adolescents. Literature searches were conducted using PubMed and PsycINFO. A total of 79 fNIRS studies involving healthy individuals aged 3-17 years that were published in peer-reviewed journals in English before July 2020 were included. Six methodological aspects of these studies were evaluated, including the research design, experimental paradigm, fNIRS measurement, data preprocessing, statistical analysis, and result presentation. The risk of bias, such as selective outcome reporting, was assessed throughout the review. A qualitative synthesis of study findings in terms of the factor effects on changes in oxyhemoglobin concentration was also performed. This unregistered review highlights the strengths and limitations of the existing literature and suggests directions for future research to facilitate the improved use of fNIRS in developmental cognitive neuroscience research.
尽管经过了几十年的研究，但由于某些神经影像学模式带来的挑战，我们对于儿童和青少年整个大脑功能发育的理解仍然有限。最近，人们越来越感兴趣地使用功能性近红外光谱（fNIRS）来阐明认知和社会情感发展的神经基础，并确定塑造这些发展类型的因素。本文聚焦于 fNIRS 方法，对目前已有的、用 fNIRS 研究来探讨年龄和其他因素对儿童和青少年大脑功能影响的文章进行了系统性综述。文献检索使用了 PubMed 和 PsycINFO。共纳入了 79 项使用 fNIRS 对 3-17 岁健康个体进行研究的文献，这些文献均发表于 2020 年 7 月前的同行评审期刊上。对这些研究的六个方法学方面进行了评估，包括研究设计、实验范式、fNIRS 测量、数据预处理、统计分析和结果呈现。在整个综述过程中，评估了选择性结果报告等偏倚风险。还对氧合血红蛋白浓度变化的因素影响进行了研究结果的定性综合。这项未注册的综述突出了现有文献的优缺点，并为未来的研究提供了方向，以促进 fNIRS 在发展认知神经科学研究中的更好应用。
