用产自巴西的抗蛇毒血清中和矛头蝮蛇毒引起的止血紊乱。

Neutralization of hemostatic disorders induced by Lachesis muta venom using Brazilian antivenoms.

机构信息

Departamento de Epidemiologia e Saúde Pública, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil.

出版信息

Toxicon. 2021 Feb;191:44-47. doi: 10.1016/j.toxicon.2020.12.013. Epub 2020 Dec 24.

DOI:10.1016/j.toxicon.2020.12.013

PMID:33359389

Abstract

We characterized the hemorrhagic, coagulant and defibrinogenant activities of Lachesis muta venom and evaluated the capacity of the Brazilian antivenoms in neutralizing these activities. The hemorrhagic activity of L. muta venom was similarly neutralized by Bothrops, Bothrops-Lachesis and Bothrops-Crotalus antivenoms. The coagulant and defibrinogenant activities were better neutralized by the Bothrops-Lachesis antivenom. Bothrops-Crotalus antivenom also neutralized these activities, indicating that it can be an alternative to treat Lachesis envenomations when Bothrops-Lachesis antivenom is unavailable.

摘要

我们对矛头蝮蛇属蛇毒的出血、凝血和纤维蛋白溶解活性进行了特征描述，并评估了巴西抗蛇毒血清中和这些活性的能力。矛头蝮蛇属蛇毒的出血活性同样被 Bothrops、Bothrops-Lachesis 和 Bothrops-Crotalus 抗蛇毒血清中和。凝血和纤维蛋白溶解活性则被 Bothrops-Lachesis 抗蛇毒血清更好地中和。Bothrops-Crotalus 抗蛇毒血清也中和了这些活性，这表明当 Bothrops-Lachesis 抗蛇毒血清不可用时，它可以作为治疗矛头蝮蛇属蛇咬伤的一种替代选择。