来自蓝藻地衣光滑肾盘衣的氯化双蒽酮类化合物。

Chlorinated bianthrones from the cyanolichen Nephroma laevigatum.

作者信息

Lagarde Aurélie, Mambu Lengo, Mai Phuong-Y, Champavier Yves, Stigliani Jean-Luc, Beniddir Mehdi A, Millot Marion

机构信息

Departement de Pharmacognosie, Faculté de Pharmacie, Université de Limoges, 2 rue du Dr Marcland, 87025 Limoges Cedex, France.

出版信息

Fitoterapia. 2021 Mar;149:104811. doi: 10.1016/j.fitote.2020.104811. Epub 2021 Jan 7.

DOI:10.1016/j.fitote.2020.104811

PMID:33359429

Abstract

While depsidones, depsides or dibenzofuran-like compounds dominate the chemical composition of lichens, the cyanolichen Nephroma laevigatum affords a diversity of quinoid pigments represented by chlorinated anthraquinones derived from emodin and new bianthrones resulting from the homo- or heterodimerization of monomers. Bianthrones were pointed out from the dichloromethane extract by MS/MS-based molecular networking, then isolated and characterized on the basis of extensive spectroscopic analyzes and GIAO NMR shift calculation followed by CP3 analyzes.

摘要

虽然缩酚酸酮、缩酚酸或二苯并呋喃类化合物在地衣的化学成分中占主导地位，但蓝藻地衣光滑黑瘤衣含有多种醌类色素，以大黄素衍生的氯化蒽醌和单体同二聚化或异二聚化产生的新双蒽酮为代表。通过基于串联质谱的分子网络从二氯甲烷提取物中指出双蒽酮，然后在广泛的光谱分析和GIAO NMR位移计算以及CP3分析的基础上进行分离和表征。