School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, UK.
Chemistry, School of Physical Sciences and Computing, University of Central Lancashire, Preston PR1 2HE, UK.
Bioorg Chem. 2019 Oct;91:103151. doi: 10.1016/j.bioorg.2019.103151. Epub 2019 Jul 24.
The synthesis of a variety of 1,8-substituted anthraquinones, anthrones and bianthrones and their potential as antifungal agents is evaluated. Preliminary screening against Schizosaccharomyces pombe (S. pombe), a fission yeast, and Saccharomyces cerevisiae (S. cerevisiae), a budding yeast, is reported. Both these yeast species demonstrate close homologue to a number of pathogenic fungi.
评估了各种 1,8-取代蒽醌、蒽酮和双蒽酮的合成及其作为抗真菌剂的潜力。报道了对裂殖酵母（Schizosaccharomyces pombe，S. pombe）和酿酒酵母（Saccharomyces cerevisiae，S. cerevisiae）的初步筛选，这两种酵母与许多致病性真菌具有密切的同源性。
