Department of Gastroenterology, Hepatology, and Nutrition, Baylor College of Medicine, Houston, TX; Children's Nutrition Research Center, Agriculture Research Services, United States Department of Agriculture, Houston, TX.
Department of Gastroenterology, Hepatology, and Nutrition, Baylor College of Medicine, Houston, TX; Children's Nutrition Research Center, Agriculture Research Services, United States Department of Agriculture, Houston, TX.
J Pediatr. 2021 Apr;231:117-123. doi: 10.1016/j.jpeds.2020.12.048. Epub 2020 Dec 23.
To test the hypothesis that in children with dyspepsia, prospective symptom severity following ingestion of a meal would correlate with percent gastric retention, and those ultimately diagnosed with gastroparesis would report worse symptoms.
Prospective, single-center study with 104 children with dyspepsia completing a prospective dyspepsia symptom questionnaire before and after eating a standardized Tougas meal during gastric emptying scintigraphy. Main outcomes included correlation between gastric retention and symptoms and comparison of symptom severity between those with and without gastroparesis.
Fifty-two children (50%) had gastroparesis (gastroparesis: 12.5 ± 2.9 years, 65% female; nongastroparesis: 13.0 ± 2.9 years, 60% female; all P > .05). Bloating was the only symptom significantly worse in youth with gastroparesis. For the entire cohort, bloating and fullness correlated with percent retention. However, in those with gastroparesis, only nausea correlated with retention (4 hours.; r = 0.275, P < .05). Girls with gastroparesis had significantly worse symptoms (except satiety) when compared with boys with gastroparesis (P < .05).
Overall in children, there is little difference in symptom severity between children with gastroparesis vs normal emptying based on current standards. However, girls with gastroparesis have worse symptoms vs boys with gastroparesis, underscoring a need for further studies into the role of sex in gastroparesis symptoms. In all children, both bloating and fullness correlated modestly with gastric retention, and nausea correlated in those with gastroparesis.
验证以下假设，即在消化不良的儿童中，摄入餐后的预期症状严重程度与胃潴留百分比相关，而最终被诊断为胃轻瘫的儿童则会报告更严重的症状。
前瞻性、单中心研究，104 名消化不良儿童在胃排空闪烁成像期间摄入标准化 Tougas 餐后，前瞻性完成消化不良症状问卷。主要结局包括胃潴留与症状之间的相关性，以及有无胃轻瘫的儿童之间症状严重程度的比较。
52 名儿童（50%）患有胃轻瘫（胃轻瘫：12.5±2.9 岁，65%为女性；非胃轻瘫：13.0±2.9 岁，60%为女性；所有 P>.05）。腹胀是胃轻瘫患儿唯一明显更严重的症状。对于整个队列，腹胀和饱胀与保留率相关。然而，在患有胃轻瘫的儿童中，只有恶心与保留率相关（4 小时；r=0.275，P<.05）。与胃轻瘫男孩相比，患有胃轻瘫的女孩症状明显更严重（除了饱腹感）（P<.05）。
总体而言，根据目前的标准，患有胃轻瘫与排空正常的儿童在症状严重程度方面几乎没有差异。然而，患有胃轻瘫的女孩的症状比患有胃轻瘫的男孩更严重，这突显了需要进一步研究性别在胃轻瘫症状中的作用。在所有儿童中，腹胀和饱胀与胃潴留中度相关，而在患有胃轻瘫的儿童中，恶心与胃潴留相关。
