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在 COVID-19 时代,使用二氧化碳描记法验证紧急呼吸机共享。

Use of capnography to verify emergency ventilator sharing in the COVID-19 era.

机构信息

Department of Anaesthesiology and Intensive Therapy, University of Szeged, 6 Semmelweis Street, H 6725, Szeged, Hungary.

Department of Medical Physics and Informatics, University of Szeged, 9 Koranyi Fasor, H 6720, Szeged, Hungary.

出版信息

Respir Physiol Neurobiol. 2021 Mar;285:103611. doi: 10.1016/j.resp.2020.103611. Epub 2020 Dec 24.

Abstract

Exacerbation of COVID-19 pandemic may lead to acute shortage of ventilators, which may require shared use of ventilator as a lifesaving concept. Two model lungs were ventilated with one ventilator to i) test the adequacy of individual tidal volumes via capnography, ii) assess cross-breathing between lungs, and iii) offer a simulation-based algorithm for ensuring equal tidal volumes. Ventilation asymmetry was induced by placing rubber band around one model lung, and the uneven distribution of tidal volumes (VT) was counterbalanced by elevating airflow resistance (HR) contralaterally. VT, end-tidal CO concentration (ETCO), and peak inspiratory pressure (Ppi) were measured. Unilateral LC reduced VT and elevated ETCO on the affected side. Under HR, VT and ETCO were re-equilibrated. In conclusion, capnography serves as simple, bedside method for controlling the adequacy of split ventilation in each patient. No collateral gas flow was observed between the two lungs with different time constants. Ventilator sharing may play a role in emergency situations.

摘要

COVID-19 大流行的恶化可能导致呼吸机严重短缺,这可能需要作为救生概念共享使用呼吸机。两个模型肺通过一个呼吸机通气,以:i)通过二氧化碳描记术测试每个潮气量的充足性,ii)评估肺之间的交叉呼吸,和 iii)提供基于模拟的算法以确保相等的潮气量。通过在一个模型肺周围放置橡皮筋来诱导通气不对称,并通过在对侧升高气流阻力(HR)来平衡潮气量(VT)的不均匀分布。测量潮气量(VT)、呼气末 CO 浓度(ETCO)和吸气峰压(Ppi)。单侧 LC 降低了患侧的 VT 和升高了 ETCO。在 HR 下,VT 和 ETCO 重新平衡。总之,二氧化碳描记术可作为控制每个患者分侧通气充足性的简单床边方法。具有不同时间常数的两个肺之间没有观察到侧流气体。呼吸机共享可能在紧急情况下发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9223/7832691/f3f2b2614282/gr1_lrg.jpg

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