Department of Dermatology & STD, University College of Medical Sciences (University of Delhi) and GTB Hospital, Delhi, India.
Department of Microbiology, University College of Medical Sciences, Delhi 110095, India.
J Mycol Med. 2021 Mar;31(1):101087. doi: 10.1016/j.mycmed.2020.101087. Epub 2020 Nov 19.
Resistant superficial dermatophytic infections of the skin and its appendages have emerged as a major health problem in India. Mutations in Squalene epoxidase gene have led to increasing incidence of resistance to terbinafine in dermatophytic isolates. We examined six patients with recalcitrant dermatophytosis attending Dermatology OPD at a tertiary care hospital and demonstrated terbinafine resistance by molecular method. Immediate hyperitivity (IH) reaction to Trichophytin antigen was highlighted in these patients. The patients were treated with alternate antifungals after demonstration of resistance to terbinafine based on the antifungal susceptibility testing (AFST). On follow up the patients responded well to the substitute but the duration of therapy had to be prolonged beyond six weeks.
印度出现了皮肤及其附属物的耐药浅表皮肤真菌病，这已成为一个主要的健康问题。角鲨烯环氧化酶基因突变导致皮肤真菌病分离株对特比萘芬的耐药性不断增加。我们通过分子方法检查了在一家三级护理医院皮肤科就诊的六位患有顽固性皮肤真菌病的患者，证明他们对特比萘芬有耐药性。这些患者对 Trichophytin 抗原立即出现超敏（IH）反应。在基于抗真菌药敏试验 (AFST) 证明对特比萘芬耐药后，这些患者改用替代抗真菌药物治疗。在随访中，患者对替代药物反应良好，但治疗时间必须延长至六周以上。
