Sacheli Rosalie, Hayette Marie-Pierre
Belgian National Reference Center, Department of Clinical Microbiology, University Hospital of Liege, 4000 Liège, Belgium.
J Fungi (Basel). 2021 Nov 18;7(11):983. doi: 10.3390/jof7110983.
Numerous reports describe the emergence of resistance in dermatophytes, especially in and strains. We here present a review of the current status of resistance in dermatophytes worldwide. Resistance to terbinafine is mainly discussed, with different mutations found in the squalene epoxidase gene also considered. Resistance to azoles is also approached. Clinical presentations caused by resistant dermatophytes are presented, together with alternative therapies that help to better manage these kind of infections.
许多报告描述了皮肤癣菌耐药性的出现，尤其是在[具体菌株1]和[具体菌株2]菌株中。我们在此对全球皮肤癣菌耐药性的现状进行综述。主要讨论了对特比萘芬的耐药性，同时也考虑了在角鲨烯环氧酶基因中发现的不同突变。还探讨了对唑类药物的耐药性。介绍了由耐药皮肤癣菌引起的临床表现，以及有助于更好地管理这类感染的替代疗法。
