Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 201204, China.
Department of Pharmacy, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 201204, China.
Chemosphere. 2021 Apr;268:129375. doi: 10.1016/j.chemosphere.2020.129375. Epub 2020 Dec 24.
Prenatal exposure to organophosphate flame retardants (OPFRs) has been associated with adverse pregnancy outcomes including low birth weight and preterm birth. However, no study has addressed the impacts of OPFRs exposure on spontaneous abortion (SAB) and fetal chromosome abnormalities. We examined whether prenatal exposure to OPFRs was associated with increased risk of SAB and fetal chromosome abnormalities. A total of 272 pregnant women, including 136 SAB cases and 136 healthy controls, were enrolled in this case-control study. Urinary concentrations of 3 OPFRs metabolites (diphenyl phosphate (DPHP), bis (1,3-dichloro-2-propyl) phosphate (BDCIPP) and bis (1-chloro-2-propyl) phosphate (BCIPP)) were measured using ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS). More than 70% of the urine samples detected quantifiable levels of 3 OPFRs metabolites. Concentrations of BCIPP were significantly higher in SAB cases than in healthy controls. Higher urinary BCIPP levels were associated with increased risk of SAB. Per unit increase in ln-transformed BCIPP concentrations was associated with 103% (OR = 2.03, 95% CI, 1.57, 2.63) increase in the odds of SAB. While higher BDCIPP levels were associated with increased risk of fetal chromosome abnormalities and the corresponding OR associated with a unit increase in ln-transformed BDCIPP concentrations were 2.34 (95% CI, 1.14, 4.81). Our results suggested the potential developmental toxicity and teratogenicity of some OPFRs.
产前接触有机磷酸酯阻燃剂 (OPFRs) 与不良妊娠结局有关，包括低出生体重和早产。然而，尚无研究探讨 OPFRs 暴露对自然流产 (SAB) 和胎儿染色体异常的影响。我们研究了产前暴露于 OPFRs 是否与 SAB 和胎儿染色体异常的风险增加有关。这项病例对照研究共纳入 272 名孕妇，包括 136 例 SAB 病例和 136 例健康对照。采用超高效液相色谱串联质谱法 (UHPLC-MS/MS) 测定 3 种 OPFRs 代谢物 (磷酸二苯酯 (DPHP)、双 (1,3-二氯-2-丙基) 磷酸酯 (BDCIPP) 和双 (1-氯-2-丙基) 磷酸酯 (BCIPP)) 的尿浓度。超过 70%的尿液样本检测到 3 种 OPFRs 代谢物的可量化水平。SAB 病例的 BCIPP 浓度明显高于健康对照组。BCIPP 浓度越高，SAB 的风险越大。ln 转化后 BCIPP 浓度每增加一个单位，SAB 的比值比 (OR) 增加 103%（OR=2.03，95%CI，1.57，2.63）。而 BDCIPP 浓度越高，与胎儿染色体异常的风险增加相关，ln 转化后 BDCIPP 浓度每增加一个单位，相应的比值比 (OR) 为 2.34（95%CI，1.14，4.81）。我们的结果表明，一些 OPFRs 具有潜在的发育毒性和致畸性。
