Department of Engineering, The University of Illinois, Chicago, IL, USA.
Department of Neurology, The University of Chicago, Chicago, IL, USA.
Clin Neurophysiol. 2021 Jan;132(1):80-93. doi: 10.1016/j.clinph.2020.10.007. Epub 2020 Oct 31.
To describe the spatio-temporal dynamics and interactions during linguistic and memory tasks.
Event-related electrocorticographic (ECoG) spectral patterns obtained during cognitive tasks from 26 epilepsy patients (aged: 9-60 y) were analyzed in order to examine the spatio-temporal patterns of activation of cortical language areas. ECoGs (1024 Hz/channel) were recorded from 1567 subdural electrodes and 510 depth electrodes chronically implanted over or within the frontal, parietal, occipital and/or temporal lobes as part of their surgical work-up for intractable seizures. Six language/memory tasks were performed, which required responding verbally to auditory or visual word stimuli. Detailed analysis of electrode locations allowed combining results across patients.
Transient increases in induced ECoG gamma power (70-100 Hz) were observed in response to hearing words (central superior temporal gyrus), reading text and naming pictures (occipital and fusiform cortex) and speaking (pre-central, post-central and sub-central cortex).
Between these activations there was widespread spatial divergence followed by convergence of gamma activity that reliably identified cortical areas associated with task-specific processes.
The combined dataset supports the concept of functionally-specific locally parallel language networks that are widely distributed, partially interacting in succession to serve the cognitive and behavioral demands of the tasks.
描述语言和记忆任务期间的时空动态和相互作用。
为了检查皮质语言区域的激活时空模式，分析了 26 名癫痫患者（年龄：9-60 岁）在认知任务期间获得的事件相关脑电图（ECoG）谱模式。ECoGs（1024 Hz/通道）是从 1567 个硬膜下电极和 510 个深部电极记录的，这些电极作为他们难治性癫痫手术评估的一部分，被慢性植入额、顶、枕和/或颞叶内或上方。进行了六项语言/记忆任务，需要口头响应听觉或视觉单词刺激。对电极位置的详细分析允许跨患者组合结果。
在听到单词（中央上颞叶）、阅读文本和命名图片（枕叶和梭状回）以及说话（中央前回、中央后回和中央下回）时，观察到诱导 ECoG 伽马功率（70-100 Hz）的短暂增加。
在这些激活之间，伽马活动的广泛空间发散随后收敛可靠地识别出与任务特定过程相关的皮质区域。
综合数据集支持功能特异性局部并行语言网络的概念，这些网络广泛分布，部分连续相互作用以满足任务的认知和行为需求。
