Division of Family Medicine and Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital; and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Division of Family Medicine and Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital; and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China; Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Nutrition. 2021 Mar;83:111071. doi: 10.1016/j.nut.2020.111071. Epub 2020 Nov 19.
Skeletal muscle mass with function decline indicated as sarcopenia, which may cause disability in elderly adults. Studies regarding fat composition in sarcopenia have gained attraction recently; however, different fat indexes have yielded different findings. It is necessary to explore the association between muscle mass, muscle function, and fat indexes among elderly adults.
Community-dwelling elderly adults ages 65 and older who received annual health examination or outpatient services were enrolled. Hand grip strength and gait speed were measured. Muscle and fat mass were estimated by bioelectrical impedance analyzer. Presarcopenia was defined as loss of muscle mass only; sarcopenia was loss of muscle mass accompanied by low grip strength or/and slow gait speed. The relationships between sarcopenia parameters and different fat indexes among elderly adults were analyzed.
There were 295 participants recruited. The presarcopenia group showed lower fat indexes compared to the sarcopenia group. Negative correlations existed between sarcopenia parameters (skeletal muscle mass index, grip strength, gait speed) and fat indexes (body-fat percentage, fat-to-muscle ratio). In the multiple hierarchical regression model, gait speed was negatively associated with body-fat percentage (β = -0.255, P = 0.009) and fat-to-muscle ratio (β = -0.272, P = 0.005) in the male group. In the female group, grip strength was inversely associated with body-fat percentage (β = -0.232, P = 0.009) and fat-to-muscle ratio (β = -0.195, P = 0.031).
Individuals in the presarcopenia group had lower fat indexes than those in the sarcopenia group. Gait speed in men and hand grip strength in women-but not muscle mass for either- were negatively associated with body-fat percentage and fat-to-muscle ratio.
骨骼肌质量下降伴功能减退表现为肌肉减少症，可导致老年人失能。近期，有关肌肉减少症脂肪成分的研究受到关注，然而不同的脂肪指标得出的结果存在差异，有必要探讨老年人肌肉量、肌肉功能与脂肪指标之间的关系。
纳入在社区接受年度体检或门诊服务的 65 岁及以上老年人，测量握力和步速，使用生物电阻抗分析仪评估肌肉和脂肪量，定义单纯肌肉量减少为预肌肉减少症，肌肉量减少伴握力低或/和步速慢为肌肉减少症。分析老年人肌肉减少症参数与不同脂肪指标的关系。
共纳入 295 名研究对象，预肌肉减少症组的脂肪指标较肌肉减少症组低。肌肉减少症参数（骨骼肌质量指数、握力、步速）与脂肪指标（体脂百分比、脂肪与肌肉比）呈负相关。在多元逐步回归模型中，男性组步速与体脂百分比（β=-0.255，P=0.009）和脂肪与肌肉比（β=-0.272，P=0.005）呈负相关；女性组握力与体脂百分比（β=-0.232，P=0.009）和脂肪与肌肉比（β=-0.195，P=0.031）呈负相关。
预肌肉减少症组的脂肪指标低于肌肉减少症组，男性组步速和女性组握力与体脂百分比和脂肪与肌肉比呈负相关，而肌肉量与两者均无关。
