β 频段去同步化与耐药性局灶性癫痫皮肤电反馈疗效有关吗？
Is beta band desynchronization related to skin conductance biofeedback effectiveness in drug resistant focal epilepsy?
机构信息
IRCCS Bologna Institute of Neurological Sciences, Bologna, Italy; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Aix Marseille Univ., INSERM, INS, Inst. Neurosci. Syst., Marseille, France.
出版信息
Epilepsy Res. 2021 Jan;169:106528. doi: 10.1016/j.eplepsyres.2020.106528. Epub 2020 Dec 10.
Skin Conductance Biofeedback (SCB) is a non-invasive behavioral treatment for epilepsy based on modulation of Galvanic Skin Response (GSR). We evaluated changes in functional connectivity occurring after SCB. Six patients with drug-resistant temporal lobe epilepsy underwent monthly SCB sessions. For each patient, 10 min of resting-state magnetoencephalographic (MEG) recording were acquired before and after the first and the last SCB session. For each recording we computed the mean weighted phase lag index (WPLI) across all pair of MEG sensors. After SCB, two patients had consistent reduction of seizure frequency (>50 %). Connectivity analysis revealed a decrease of WPLI-beta band in the two responders and an increase of WPLI-alpha connectivity in all patients regardless of the clinical effect. Results suggest that reduction of WPLI-beta-low connectivity is related to the clinical response after SCB.
皮肤电传导生物反馈（SCB）是一种基于皮肤电传导反应（GSR）调节的非侵入性癫痫行为治疗方法。我们评估了 SCB 后发生的功能连接变化。六名耐药性颞叶癫痫患者接受了每月一次的 SCB 治疗。对于每位患者，在第一次和最后一次 SCB 治疗前后，都进行了 10 分钟的静息状态脑磁图（MEG）记录。对于每个记录，我们计算了所有 MEG 传感器对之间的平均加权相位滞后指数（WPLI）。在 SCB 之后，两名患者的癫痫发作频率持续降低（>50%）。连通性分析显示，在两名应答者中，β 波段的 WPLI 降低，而在所有患者中，无论临床效果如何，α 波段的 WPLI 连通性都增加。结果表明，β 波段低连通性的 WPLI 降低与 SCB 后的临床反应有关。
Zotero 插件