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[牙干细胞:神经再生医学中的神话还是希望?]

[Dental stem cells: myth or hope in neuroregenerative medicine?].

作者信息

Dimassi Syrine, Relaño-Ginés Aroa, Hirtz Christophe, Lehmann Sylvain, Deville de Périère Dominique

机构信息

DERBS, Univ Montpellier, Faculté d'odontologie, Montpellier, France, IRMB, Univ Montpellier, Inserm, CHU Montpellier, CNRS, Montpellier, France.

IRMB, Univ Montpellier, Inserm, CHU Montpellier, CNRS, Montpellier, France.

出版信息

Ann Biol Clin (Paris). 2020 Dec 1;78(6):593-603. doi: 10.1684/abc.2020.1611.

Abstract

The use of dental stem cells has raised many hopes in the development of new treatments for neurodegenerative diseases. According to current statistics, about 1 in 6 people in the world would be affected by a neurological disease. This number continues to increase as the world's population ages, making neurodegenerative diseases probably the one of the major challenges of public health in the 21st century. Neurodegenerative diseases are characterized mainly by a progressive loss of cognitive abilities and patient autonomy related to loss and degeneration of neurons in brain structures. Unfortunately, today, the only treatments available for this type of disease do only relieve the symptoms, they do not treat them, and few clinical trials have been truly convincing to date. Hence, hope lies for these diseases in the development of other therapeutic approaches. As such, dental stem cells could be a promising area of research because of their rapid growth, their great capacity for differentiation into different types of cells (among neuronal ones for some of them) and how easy they can be obtained, without raising ethical issues as for example for embryonic stem cells.

摘要

牙干细胞的应用为神经退行性疾病新疗法的开发带来了诸多希望。根据目前的统计数据,全球约六分之一的人会受到神经疾病的影响。随着世界人口老龄化,这一数字持续上升,神经退行性疾病可能成为21世纪公共卫生领域的主要挑战之一。神经退行性疾病的主要特征是认知能力逐渐丧失以及患者自主性下降,这与脑结构中神经元的丢失和退化有关。不幸的是,目前针对这类疾病的唯一治疗方法只能缓解症状,无法治愈,而且迄今为止,很少有临床试验真正令人信服。因此,开发其他治疗方法有望攻克这些疾病。就此而言,牙干细胞可能是一个有前景的研究领域,因为它们生长迅速,具有分化为不同类型细胞(其中一些可分化为神经元细胞)的强大能力,而且获取容易,不像胚胎干细胞那样会引发伦理问题。

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