金属微量营养素水平异常与自闭症谱系障碍：一篇综述
Abnormal Levels of Metal Micronutrients and Autism Spectrum Disorder: A Perspective Review.
作者信息
Behl Supriya, Mehta Sunil, Pandey Mukesh K
机构信息
Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, United States.
Department of Radiology, Mayo Clinic, Rochester, MN, United States.
出版信息
Front Mol Neurosci. 2020 Dec 10;13:586209. doi: 10.3389/fnmol.2020.586209. eCollection 2020.
Abstract
The aim of the present review is to summarize the prevalence of abnormal levels of various metal micronutrients including copper (Cu), iron (Fe), magnesium (Mg), zinc (Zn), and selenium (Se) in Autism Spectrum Disorder (ASD) using hair, nail and serum samples. A correlation of selected abnormal metal ions with known neurodevelopmental processes using Gene Ontology (GO) term was also conducted. Data included in this review are derived from ASD clinical studies performed globally. Metal ion disparity data is also analyzed and discussed based on gender (Male/Female) to establish any gender dependent correlation. Finally, a rational perspective and possible path to better understand the role of metal micronutrients in ASD is suggested.
摘要
本综述的目的是总结使用头发、指甲和血清样本，在自闭症谱系障碍（ASD）中各种金属微量元素，包括铜（Cu）、铁（Fe）、镁（Mg）、锌（Zn）和硒（Se）异常水平的患病率。还使用基因本体论（GO）术语对选定的异常金属离子与已知神经发育过程进行了相关性分析。本综述纳入的数据来自全球范围内开展的ASD临床研究。还基于性别（男性/女性）对金属离子差异数据进行了分析和讨论，以确定是否存在任何性别依赖性相关性。最后，提出了一个合理的观点以及更好理解金属微量元素在ASD中作用的可能途径。
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