Faculty of Medicine, The Federal University of Mato Grosso do Sul, Campo Grande, Brazil.
Council for Nutritional and Environmental Medicine, Toften 24, 8610 Mo i Rana, Norway.
Biomed Pharmacother. 2018 Oct;106:605-609. doi: 10.1016/j.biopha.2018.06.174. Epub 2018 Jul 11.
The association between the plasma levels of trace elements, such as copper (Cu), zinc (Zn) and selenium (Se), in people with autism spectrum disorder (ASD), has attracted the interest of many physicians in the very recent years, because the impaired homeostatic regulation of trace elements, including their levels in the bloodstream and their potential neurotoxicity, contribute to the onset and exacerbation of ASD. In this study, we investigated 23 pediatric subjects (≤ 18 yrs old, both sexes) with ASD, all residents in the city of Campo Grande in Brazil, by searching for their micronutrient levels in plasma in relation with metabolic and nutrition biomarkers. Aside for the few evidence reported, generally, the Brazilian cohort of ASD children here examined did not show a marked difference in micro-nutrient intake in relation with their resident geographical area and their dietary habit or metabolic state, although a slight difference in the levels of magnesium and phosphorus was retrieved due to sex difference.
近年来，人们对自闭症谱系障碍（ASD）患者血浆中微量元素（如铜（Cu）、锌（Zn）和硒（Se））水平的相关性产生了浓厚的兴趣，因为微量元素（包括其在血液中的水平及其潜在的神经毒性）的内稳态调节受损，导致 ASD 的发生和恶化。在这项研究中，我们调查了 23 名儿科患者（≤ 18 岁，男女不限）患有 ASD，他们均居住在巴西坎波格兰德市，通过寻找他们血浆中的微量营养素水平与代谢和营养生物标志物的关系。除了少数报道的证据外，一般来说，我们在这里检查的巴西 ASD 儿童队列并没有表现出与他们居住的地理区域、饮食习惯或代谢状态有关的明显的微量营养素摄入差异，尽管由于性别差异，镁和磷的水平略有差异。
