Zhang Yingxia, Chen Hong, Zeng Min, He Junwei, Qi Guiqiang, Zhang Shaojin, Liu Rongbo
Department of Radiology, West China Hospital of Sichuan University, Chengdu, China.
Department of Radiology, The Third Affiliated Hospital of Chengdu Medical College, Pidu District People's Hospital, Chengdu, China.
Front Hum Neurosci. 2020 Dec 11;14:619839. doi: 10.3389/fnhum.2020.619839. eCollection 2020.
Previous studies have reported abnormal amplitude of low-frequency fluctuation and regional homogeneity in patients with migraine without aura using resting-state functional magnetic resonance imaging. However, how whole brain functional connectivity pattern homogeneity and its corresponding functional connectivity changes in patients with migraine without aura is unknown. In the current study, we employed a recently developed whole brain functional connectivity homogeneity (FcHo) method to identify the voxel-wise changes of functional connectivity patterns in 21 patients with migraine without aura and 21 gender and age matched healthy controls. Moreover, resting-state functional connectivity analysis was used to reveal the changes of corresponding functional connectivities. FcHo analyses identified significantly decreased FcHo values in the posterior cingulate cortex (PCC), thalamus (THA), and left anterior insula (AI) in patients with migraine without aura compared to healthy controls. Functional connectivity analyses further found decreased functional connectivities between PCC and medial prefrontal cortex (MPFC), between AI and anterior cingulate cortex, and between THA and left precentral gyrus (PCG). The functional connectivities between THA and PCG were negatively correlated with pain intensity. Our findings indicated that whole brain FcHo and connectivity abnormalities of these regions may be associated with functional impairments in pain processing in patients with migraine without aura.
以往研究利用静息态功能磁共振成像报告了无先兆偏头痛患者低频波动幅度和局部一致性异常。然而，无先兆偏头痛患者全脑功能连接模式一致性及其相应的功能连接变化情况尚不清楚。在本研究中，我们采用了一种最近开发的全脑功能连接一致性（FcHo）方法，来识别21例无先兆偏头痛患者以及21例年龄和性别匹配的健康对照者功能连接模式的体素水平变化。此外，静息态功能连接分析用于揭示相应功能连接的变化。FcHo分析发现，与健康对照相比，无先兆偏头痛患者的后扣带回皮质（PCC）、丘脑（THA）和左侧前岛叶（AI）的FcHo值显著降低。功能连接分析进一步发现，PCC与内侧前额叶皮质（MPFC）之间、AI与前扣带回皮质之间以及THA与左侧中央前回（PCG）之间的功能连接减少。THA与PCG之间的功能连接与疼痛强度呈负相关。我们的研究结果表明，这些区域的全脑FcHo和连接异常可能与无先兆偏头痛患者疼痛处理中的功能损害有关。
