Department of Psychiatry, Xiamen Xianyue Hospital, Xiamen, China.
School of Mental Health, Jining Medical University, Jining, China.
Brain Behav. 2022 May;12(5):e2580. doi: 10.1002/brb3.2580. Epub 2022 Apr 21.
Previous neuroimaging studies have extensively demonstrated many signs of functionally spontaneous local neural activity abnormalities in bipolar disorder (BD) patients using resting-state functional magnetic resonance imaging (rs-fMRI). However, how to identify the changes of voxel-wise whole-brain functional connectivity pattern and its corresponding functional connectivity changes remain largely unclear in BD patients. The current study aimed to investigate the voxel-wise changes of functional connectivity patterns in BD patients using publicly available data from the UCLA CNP LA5c Study.
A total of 45 BD patients and 115 healthy control subjects were finally included and whole-brain functional connectivity homogeneity (FcHo) was calculated from their rs-fMRI. Moreover, the alterations of corresponding functional connectivity were subsequently identified using seed-based resting-state functional connectivity analysis.
Individuals with BD exhibited significantly lower FcHo values in the left middle temporal gyrus (MTG) when compared with controls. Functional connectivity findings further indicated decreased functional connectivities between left MTG and cluster 1 (left superior temporal gyrus, extend to middle temporal gyrus, rolandic operculum), cluster 2 (right postcentral, extend to right precentral) in BD patients. The mean FcHo values of left MTG were positively correlated with insomnia, middle scores and appetite increase scores. The mean functional connectivities of left MTG to cluster 1 were negatively correlated with grandiose delusions scores. While the functional connections between left MTG with cluster 2 were negatively correlated with delusions of reference and positively correlated with insomnia, middle scores in BD patients.
Our findings suggested that abnormal FcHo and functional connections in those areas of the brain involving DMN and SMN networks might play a crucial role in the neuropathology of BD.
先前的神经影像学研究使用静息态功能磁共振成像（rs-fMRI）广泛证明了双相障碍（BD）患者局部神经活动异常的许多功能自发性迹象。然而，如何识别体素全脑功能连接模式的变化及其在 BD 患者中的相应功能连接变化在很大程度上仍不清楚。本研究旨在使用来自 UCLA CNP LA5c 研究的公开数据，研究 BD 患者的体素功能连接模式变化。
最终纳入了 45 名 BD 患者和 115 名健康对照者，并从他们的 rs-fMRI 中计算了全脑功能连接同质性（FcHo）。此外，还使用基于种子的静息态功能连接分析来识别相应功能连接的改变。
与对照组相比，BD 患者的左颞中回（MTG）的 FcHo 值显著降低。功能连接发现进一步表明，BD 患者左 MTG 与簇 1（左颞上回，延伸至颞中回， Rolandic 脑岛）、簇 2（右中央后回，延伸至右中央前回）之间的功能连接减少。左 MTG 的平均 FcHo 值与失眠、中等评分和食欲增加评分呈正相关。左 MTG 与簇 1 的平均功能连接与夸大妄想评分呈负相关。而左 MTG 与簇 2 的功能连接与参照妄想呈负相关，与失眠和中等评分呈正相关。
我们的研究结果表明，DMN 和 SMN 网络相关脑区的异常 FcHo 和功能连接可能在 BD 的神经病理学中发挥关键作用。
