Dilsaver S C, Majchrzak M J
Department of Psychiatry, Ohio State University, Columbus 43210-1228.
Life Sci. 1988;42(2):225-30. doi: 10.1016/0024-3205(88)90686-8.
Bright artificial light is a treatment for seasonal depression. Eleven (11) rats were exposed to bright artificial light (11,500 lux) for two consecutive weeks. The thermic response to nicotine was measured prior to light exposure and after one and two weeks of treatment. The thermic response to nicotine at baseline was -1.69 +/- 0.25 degrees C (mean +/- SEM). The thermic response to nicotine was -0.66 +/- 0.12 degrees C (p less than 0.002) after one and +0.31 +/- 0.14 degrees C (p less than 0.000025) after two weeks of light exposure. The change in temperature was different between weeks one and two (p less than 0.000025). The exposure of animals to constant light at an intensity of 300 lux did not blunt the hypothermic response to nicotine. These findings suggest that bright artificial light, like other antidepressant treatments, produces subsensitivity of a nicotinic mechanism involved in the regulation of core temperature.
明亮的人造光是治疗季节性抑郁症的一种方法。11只大鼠连续两周暴露于明亮的人造光（11500勒克斯）下。在光照暴露前以及治疗一周和两周后测量对尼古丁的热反应。基线时对尼古丁的热反应为-1.69±0.25摄氏度（平均值±标准误）。光照暴露一周后对尼古丁的热反应为-0.66±0.12摄氏度（p<0.002），两周后为+0.31±0.14摄氏度（p<0.000025）。第一周和第二周之间的温度变化不同（p<0.000025）。将动物暴露于强度为300勒克斯的持续光照下并未减弱对尼古丁的低温反应。这些发现表明，明亮的人造光与其他抗抑郁治疗一样，会使参与核心体温调节的烟碱机制产生敏感性降低。
