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白斑角鲨肝脏中环状RNA的鉴定（）。 （注：括号内原文内容缺失）

Identification of circRNAs in the Liver of Whitespotted Bamboo Shark ().

作者信息

Zhang Wenjie, Qin Ping, Gong Xiaoxia, Huang Lei, Wang Chan, Chen Guiqian, Chen Jianqing, Wang Lei, Lv Zhengbing

机构信息

College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, China.

Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, Zhejiang Sci-Tech University, Hangzhou, China.

出版信息

Front Genet. 2020 Dec 11;11:596308. doi: 10.3389/fgene.2020.596308. eCollection 2020.

DOI:10.3389/fgene.2020.596308
PMID:33362857
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7759564/
Abstract

Whitespotted bamboo shark (), a member of the cartilaginous fish family, has an extremely large liver and demonstrates a strong regeneration ability and immune regulation. Circular RNAs (circRNAs) is an important class of non-coding RNAs. Increasing evidences suggest that circRNAs are a kind of potential regulators. Recently, researchers have isolated and identified different circRNAs from various species, while few reports were on the circRNAs of . In this study, we have identified a total of 4,558 circRNAs in the liver of . This finding suggests that circRNAs are not evenly distributed in the chromosomes and follow the GT-AG rule during cyclization. Alternative back-splicing might exist in shark circRNAs as shown by the authenticity identification of predicted circRNAs. The binding strength of circRNAs (<2,000 bp) and the detected miRNAs in shark liver were simultaneously analyzed to construct an mRNA-miRNA-circRNA network for the Glutathione S-transferase P1 gene, and the circRNA authenticity was simultaneously verified. Our data provide not only novel insights into the rich existence of circRNAs in marine animals, but also a basis for characterizing functions of identified circRNAs in the liver homeostasis of .

摘要

白点竹鲨（）是软骨鱼家族的一员，肝脏极大，具有很强的再生能力和免疫调节能力。环状RNA（circRNAs）是一类重要的非编码RNA。越来越多的证据表明，circRNAs是一种潜在的调节因子。最近，研究人员已从各种物种中分离并鉴定出不同的circRNAs，但关于的circRNAs的报道很少。在本研究中，我们在的肝脏中总共鉴定出4558种circRNAs。这一发现表明，circRNAs在染色体中并非均匀分布，并且在环化过程中遵循GT-AG规则。如预测circRNAs的真实性鉴定所示，鲨鱼circRNAs中可能存在可变反向剪接。同时分析了鲨鱼肝脏中circRNAs（<2000 bp）与检测到的miRNAs的结合强度，构建了谷胱甘肽S-转移酶P1基因的mRNA-miRNA-circRNA网络，并同时验证了circRNA的真实性。我们的数据不仅为海洋动物中circRNAs的丰富存在提供了新见解，也为表征已鉴定的circRNAs在肝脏稳态中的功能提供了基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5040/7759564/947a4344d998/fgene-11-596308-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5040/7759564/d27a7ece5d09/fgene-11-596308-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5040/7759564/5db33dd8e1c7/fgene-11-596308-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5040/7759564/c4fabc128bba/fgene-11-596308-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5040/7759564/1141222b1877/fgene-11-596308-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5040/7759564/857fc7b9a4c1/fgene-11-596308-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5040/7759564/68dd6650b39a/fgene-11-596308-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5040/7759564/947a4344d998/fgene-11-596308-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5040/7759564/d27a7ece5d09/fgene-11-596308-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5040/7759564/5db33dd8e1c7/fgene-11-596308-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5040/7759564/c4fabc128bba/fgene-11-596308-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5040/7759564/1141222b1877/fgene-11-596308-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5040/7759564/857fc7b9a4c1/fgene-11-596308-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5040/7759564/68dd6650b39a/fgene-11-596308-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5040/7759564/947a4344d998/fgene-11-596308-g007.jpg

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