环状 RNA 在肿瘤免疫调节和免疫治疗中的潜在作用。
The Potential Role of circRNA in Tumor Immunity Regulation and Immunotherapy.
机构信息
Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha, China.
Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Key Laboratory of Carcinogenesis, Ministry of Health, Cancer Research Institute, Central South University, Changsha, China.
出版信息
Front Immunol. 2018 Jan 22;9:9. doi: 10.3389/fimmu.2018.00009. eCollection 2018.
Non-coding RNAs (ncRNAs) can be divided into circular non-coding RNAs (circRNAs) and linear ncRNAs. ncRNAs exist in different cell types, including normal cells, tumor cells and immunocytes. Linear ncRNAs, such as long ncRNAs and microRNAs, have been found to play important roles in the regulation of tumor immunity and immunotherapy; however, the functions of circRNAs in tumor immunity and immunotherapy are less known. Here, we review the current status of ncRNAs in the regulation of tumor immunity and immunotherapy and emphatically discuss the potential roles of circRNAs as tumor antigens in the regulation of tumor immunity and immunotherapy.
非编码 RNA（ncRNAs）可分为环状非编码 RNA（circRNAs）和线性 ncRNAs。ncRNAs 存在于不同的细胞类型中，包括正常细胞、肿瘤细胞和免疫细胞。线性 ncRNAs，如长 ncRNAs 和 microRNAs，已被发现在肿瘤免疫和免疫治疗的调控中发挥重要作用；然而，circRNAs 在肿瘤免疫和免疫治疗中的功能知之甚少。在这里，我们综述了 ncRNAs 在肿瘤免疫和免疫治疗调控中的研究现状，并着重讨论了 circRNAs 作为肿瘤抗原在肿瘤免疫和免疫治疗调控中的潜在作用。
Zotero 插件