Lu Weidong
Leonard P. Zakim Center for Integrative Therapies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Med Acupunct. 2020 Dec 1;32(6):398-399. doi: 10.1089/acu.2020.1496. Epub 2020 Dec 16.
Chemotherapy-induced peripheral neuropathy (CIPN) induces debilitating long-term side-effects in breast cancer-survivors. This article describes some of the more-recent research in this area including a randomized controlled pilot trial the current author and colleagues performed to assess feasibility, safety, and effectiveness of acupuncture for treating CIPN in this population. In this randomized pilot trial of 40 breast-cancer survivors with CIPN after adjuvant taxane therapy, an 8-week acupuncture intervention (versus usual care) led to a statistically and clinically significant reduction in subjective sensory symptoms, including neuropathic pain and paresthesia. Given the lack of effective therapies and given the established safety profile of acupuncture, clinicians may consider acupuncture as a treatment option for mild-to-moderate CIPN in practice. Additional larger studies are needed to confirm these findings.
化疗引起的周围神经病变（CIPN）会给乳腺癌幸存者带来长期的衰弱性副作用。本文介绍了该领域的一些最新研究，包括当前作者及其同事进行的一项随机对照试验，以评估针刺疗法治疗该人群CIPN的可行性、安全性和有效性。在这项针对40名接受辅助紫杉烷治疗后出现CIPN的乳腺癌幸存者的随机试验中，为期8周的针刺干预（与常规护理相比）在主观感觉症状方面，包括神经性疼痛和感觉异常，导致了具有统计学意义和临床意义的减轻。鉴于缺乏有效的治疗方法以及针刺疗法已确立的安全性，临床医生在实践中可考虑将针刺疗法作为轻至中度CIPN的一种治疗选择。需要更多更大规模的研究来证实这些发现。
