Huang Chien-Chen, Ho Tsung-Jung, Ho Hsin-Yueh, Chen Pei-Yu, Tu Cheng-Hao, Huang Yu-Chuen, Lee Yu-Chen, Sun Mao-Feng, Chen Yi-Hung
Graduate Institute of Chinese Medicine, School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.
Department of Traditional Chinese Medicine, An Nan Hospital, China Medical University, Tainan City 709, Taiwan.
J Clin Med. 2021 Aug 20;10(16):3694. doi: 10.3390/jcm10163694.
Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling side effect caused by neurotoxic chemotherapy. This randomized controlled trial aimed to evaluate the effect of manual acupuncture on CIPN. Twenty eligible breast cancer patients receiving taxane chemotherapy treatment were recruited and randomly divided into verum acupuncture and sham acupuncture groups. Each group received 15 treatments over 9 weeks. Quantitative tactile detection thresholds were measured using Semmes-Weinstein monofilament testing (SWM). The World Health Organization Quality of Life scale (WHOQOL-BREF), the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx), and the Brief Pain Inventory-Short Form (BPI-SF) were measured before and after treatment. The between-group comparison of SWM revealed that the verum acupuncture group had more improvement of touch perception thresholds compared to the sham acupuncture group. The average pain severity in the BPI-SF of the verum acupuncture group was significantly lower than that of the sham acupuncture group. There were no significant differences in the FACT/GOG-Ntx trial outcome index and WHOQOL-BREF scores between the acupuncture and sham groups. The results suggest that acupuncture can alleviate the neuropathic pain of CIPN and improve touch perception thresholds.
化疗引起的周围神经病变（CIPN）是由神经毒性化疗导致的一种致残性副作用。这项随机对照试验旨在评估手动针刺对CIPN的疗效。招募了20名接受紫杉烷化疗的符合条件的乳腺癌患者，并将其随机分为真针刺组和假针刺组。每组在9周内接受15次治疗。使用Semmes-Weinstein单丝测试（SWM）测量定量触觉检测阈值。在治疗前后测量世界卫生组织生活质量量表（WHOQOL-BREF）、癌症治疗功能评估/妇科肿瘤学组-神经毒性（FACT/GOG-Ntx）和简明疼痛量表-简表（BPI-SF）。SWM的组间比较显示，与假针刺组相比，真针刺组的触觉感知阈值改善更多。真针刺组BPI-SF中的平均疼痛严重程度显著低于假针刺组。针刺组和假针刺组之间在FACT/GOG-Ntx试验结果指数和WHOQOL-BREF评分方面没有显著差异。结果表明，针刺可以减轻CIPN的神经性疼痛并改善触觉感知阈值。
