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2
Biased Recognition of Surprised Facial Expressions Following Awake Craniotomy of a Right Temporal Lobe Tumor.右侧颞叶肿瘤清醒开颅术后对面部惊讶表情的偏向性识别。
Front Psychol. 2019 Aug 20;10:1908. doi: 10.3389/fpsyg.2019.01908. eCollection 2019.
3
Alterations of white matter network in patients with left and right non-lesional temporal lobe epilepsy.左侧和右侧非病变颞叶癫痫患者的脑白质网络改变。
Eur Radiol. 2019 Dec;29(12):6750-6761. doi: 10.1007/s00330-019-06295-5. Epub 2019 Jul 8.
4
Network and Pathway-Based Analysis of Single-Nucleotide Polymorphism of miRNA in Temporal Lobe Epilepsy.基于 miRNA 单核苷酸多态性的颞叶癫痫的网络和通路分析。
Mol Neurobiol. 2019 Oct;56(10):7022-7031. doi: 10.1007/s12035-019-1584-4. Epub 2019 Apr 9.
5
Cognitive slowing and its underlying neurobiology in temporal lobe epilepsy.颞叶癫痫中的认知迟缓及其神经生物学基础。
Cortex. 2019 Aug;117:41-52. doi: 10.1016/j.cortex.2019.02.022. Epub 2019 Mar 5.
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颞叶癫痫患者兄弟姐妹的认知能力受损

Impaired Cognitive Abilities in Siblings of Patients with Temporal Lobe Epilepsy.

作者信息

Tan Langzi, Chen Yayu, Wu Wenyue, Liu Chaorong, Fu Yujiao, He Jialinzi, Zhang Min, Wang Ge, Wang Kangrun, Long Hongyu, Xiao Wenbiao, Xiao Bo, Long Lili

机构信息

Department of Neurology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.

出版信息

Neuropsychiatr Dis Treat. 2020 Dec 14;16:3071-3079. doi: 10.2147/NDT.S258074. eCollection 2020.

DOI:10.2147/NDT.S258074
PMID:33363375
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7752648/
Abstract

PURPOSE

Patients with temporal lobe epilepsy (TLE) are at high risk of cognitive impairment. In addition to persistent seizures and antiepileptic drugs (AEDs), genetic factors also play an important role in the progression of cognitive deficits in TLE patients. Defining a cognitive endophenotype for TLE can provide information on the risk of cognitive impairment in patients. This study investigated the cognitive endophenotype of TLE by comparing neuropsychological function between patients with TLE, their unaffected siblings, and healthy control subjects.

PATIENTS AND METHODS

A total of 46 patients with TLE, 26 siblings, and 33 control subjects were recruited. Cognitive function (ie, general cognition, short- and long-term memory, attention, visuospatial and executive functions, and working memory) was assessed with a battery of neuropsychological tests. Differences between groups were evaluated by analysis of covariance, with age and years of education as covariates. The Kruskal-Wallis test was used to evaluate data that did not satisfy the homogeneity of variance assumption. Pairwise comparisons were adjusted by Bonferroni correction, with a significance threshold of P<0.05.

RESULTS

Patients with TLE showed deficits in the information test (P<0.001), arithmetic test (P=0.003), digit symbol substitution test (P=0.001), block design test (BDT; P=0.005), and backward digit span test (P=0.001) and took a longer time to complete the Hayling test Part A (P=0.011) compared to controls. Left TLE patients tended to have worse executive function test scores than right TLE patients. The siblings of TLE patients showed deficits in the BDT (P=0.006, Bonferroni-corrected) relative to controls.

CONCLUSION

Patients with TLE exhibit cognitive impairment. Executive function is worse in patients with left TLE than in those with right TLE. Siblings show impaired visuospatial function relative to controls. Thus, cognitive deficits in TLE patients have a genetic component and are independent of seizures or AED use.

摘要

目的

颞叶癫痫(TLE)患者存在认知障碍的高风险。除了持续性癫痫发作和抗癫痫药物(AEDs)外,遗传因素在TLE患者认知缺陷的进展中也起着重要作用。定义TLE的认知内表型可为患者认知障碍风险提供信息。本研究通过比较TLE患者、其未受影响的兄弟姐妹和健康对照者之间的神经心理功能,调查了TLE的认知内表型。

患者与方法

共招募了46例TLE患者、26名兄弟姐妹和33名对照者。使用一系列神经心理测试评估认知功能(即一般认知、短期和长期记忆、注意力、视觉空间和执行功能以及工作记忆)。以年龄和受教育年限作为协变量,通过协方差分析评估组间差异。使用Kruskal-Wallis检验评估不满足方差齐性假设的数据。两两比较采用Bonferroni校正进行调整,显著性阈值为P<0.05。

结果

与对照组相比,TLE患者在信息测试(P<0.001)、算术测试(P=0.003)、数字符号替换测试(P=0.001)、积木设计测试(BDT;P=0.005)和倒背数字广度测试(P=0.001)中表现出缺陷,并且完成海林测试A部分的时间更长(P=0.011)。左侧TLE患者的执行功能测试得分往往比右侧TLE患者更差。与对照组相比,TLE患者的兄弟姐妹在BDT中表现出缺陷(P=0.006,Bonferroni校正)。

结论

TLE患者存在认知障碍。左侧TLE患者的执行功能比右侧TLE患者更差。与对照组相比,兄弟姐妹表现出视觉空间功能受损。因此,TLE患者的认知缺陷具有遗传成分,且独立于癫痫发作或AED的使用。