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NK/T细胞非霍奇金淋巴瘤:病例报告及文献综述

NK/T-cell non-Hodgkin lymphoma: Case report and review of the literature.

作者信息

Lungu Mihaiela, Telehuz Anca, Voinescu Doina Carina, Sapira Violeta, Trifan Angel, Elkan Eva Maria, Fătu Ana, Creangă Valerica Zărnescu, Polinschi Mihai, Stoleriu Gabriela, Niculet Elena

机构信息

Clinical Department, Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University of Galati, 800008 Galati, Romania.

Research Center of Medical and Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University of Galati, 800008 Galati, Romania.

出版信息

Exp Ther Med. 2021 Jan;21(1):91. doi: 10.3892/etm.2020.9523. Epub 2020 Nov 26.

Abstract

Natural killer (NK)/T-cell lymphomas represent a rare type of lymphoid malignancy with mostly extranodal involvement, having NK cell or (rare) T cell lineage, classified by the World Health Organization into several subtypes which can involve the head and neck region, with the most frequent one being the nasal type. This article presents the case of a 31-year-old patient who presented at the Emergency Unit of Saint Andrew Emergency Clinical Hospital of Galati suffering from mycosis fungoides-like cutaneous lesions, associated with partial left eyelid ptosis of unknown etiology, as well as a poor health status with fever and respiratory failure. The final diagnosis was NK/T-cell non-Hodgkin lymphoma, possibly nasal type with medium sized T cells. The complexity of the rare diagnosis, associated with the unusual rapid patient evolution towards exitus 3 months after diagnosis, the intra-orbital metastatic involvement and the absence of a standardized treatment are case peculiarities, some of which are consistent with current literature data.

摘要

自然杀伤(NK)/T细胞淋巴瘤是一种罕见的淋巴系统恶性肿瘤,多累及结外器官,起源于NK细胞或(罕见)T细胞系,世界卫生组织将其分为几个亚型,可累及头颈部区域,其中最常见的是鼻型。本文介绍了一名31岁患者的病例,该患者因蕈样肉芽肿样皮肤病变就诊于加拉茨圣安德鲁急诊临床医院急诊科,伴有病因不明的左侧部分眼睑下垂,以及发热和呼吸衰竭导致的健康状况不佳。最终诊断为NK/T细胞非霍奇金淋巴瘤,可能为鼻型伴中等大小T细胞。该罕见诊断的复杂性以及患者在诊断后3个月内迅速进展至死亡、眶内转移受累和缺乏标准化治疗等情况均为该病例的特殊之处,其中一些与当前文献数据相符。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96aa/7725024/5b9a0d33e969/etm-21-01-09523-g00.jpg

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