Gao Xu-Dong, Zhang Jin, Li An, Ding Yu, Zhao Bo, Li Lan
Department of Otolaryngology Head and Neck Surgery, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi Province, China.
Department of Hematology, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi Province, China.
World J Psychiatry. 2025 Apr 19;15(4):99346. doi: 10.5498/wjp.v15.i4.99346.
Natural killer (NK)/T-cell non-Hodgkin's lymphoma (NHL) in the nasal cavities and paranasal sinuses accounts for approximately 10% of all lymphomas, and the occurrence of nasal NHL is related to Epstein-Barr virus infection.
To explore the anxiety and depression status of patients with NK/T-cell NHL in the nasal cavities and paranasal sinuses and analyzes the relevant influencing factors.
A retrospective analysis was performed, which included 30 patients with primary nasal NK/T-cell NHL treated in Shaanxi Provincial People's Hospital from January 2017 to January 2023. An additional 50 healthy volunteers were selected as the control group. Both groups were assessed using the self-rating anxiety scale (SAS) and Self-rating (SDS). SDS and SAS scores of patients with NHL at different disease stages were analyzed, and they were further grouped into negative emotion (NE) ( = 19) and non-NE ( = 11) groups based on their depression and anxiety. Factors affecting the occurrence of NEs in patients with NHL were analyzed using univariate and multivariate logistic regression models.
Patients with NHL exhibited higher SDS and SAS scores than healthy controls. Moreover, patients with NHL at stages III and IV had higher SDS and SAS scores than those in stage I. Among the 30 patients, there were 13 patients with depression (43.3%), 16 patients with anxiety (53.3%), and 10 patients with both anxiety and depression (33.3%). Univariate analysis identified a higher proportion of people in the NE group with stage III-IV NHL, an educational level ≤ high school, and a monthly household income < 5000 yuan compared with the non-NE group. Multiple logistic regression analysis further revealed that stage III-IV was a risk factor for NEs in patients with NHL.
The stage of NK/T-cell NHL in nasal cavities and paranasal sinuses is closely related to patient anxiety and depression. The higher the staging, the greater the incidence of anxiety and depression.
鼻腔和鼻窦的自然杀伤（NK）/T细胞非霍奇金淋巴瘤（NHL）约占所有淋巴瘤的10%，鼻腔NHL的发生与爱泼斯坦-巴尔病毒感染有关。
探讨鼻腔和鼻窦NK/T细胞NHL患者的焦虑和抑郁状况，并分析相关影响因素。
进行回顾性分析，纳入2017年1月至2023年1月在陕西省人民医院接受治疗的30例原发性鼻腔NK/T细胞NHL患者。另外选取50名健康志愿者作为对照组。两组均采用自评焦虑量表（SAS）和自评抑郁量表（SDS）进行评估。分析不同疾病阶段NHL患者的SDS和SAS评分，并根据其抑郁和焦虑情况进一步分为负性情绪（NE）组（n = 19）和非NE组（n = 11）。采用单因素和多因素logistic回归模型分析影响NHL患者发生NE的因素。
NHL患者的SDS和SAS评分高于健康对照组。此外，Ⅲ期和Ⅳ期NHL患者的SDS和SAS评分高于Ⅰ期患者。30例患者中，有13例抑郁（43.3%），16例焦虑（53.3%），10例同时存在焦虑和抑郁（33.3%）。单因素分析发现，与非NE组相比，NE组中Ⅲ-Ⅳ期NHL、教育程度≤高中、家庭月收入<5000元的人群比例更高。多因素logistic回归分析进一步显示，Ⅲ-Ⅳ期是NHL患者发生NE 的危险因素。
鼻腔和鼻窦NK/T细胞NHL的分期与患者焦虑和抑郁密切相关。分期越高，焦虑和抑郁的发生率越高。
