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一例由多种抗抑郁药引起的药物性肝损伤（DILI）病例报告，采用更新后的鲁塞尔·乌克拉夫因果关系评估方法（RUCAM）及体外试验确定了因果关系。

A case report of a drug-induced liver injury (DILI) caused by multiple antidepressants with causality established by the updated Roussel Uclaf causality assessment method (RUCAM) and in vitro testing.

作者信息

González-Muñoz Miguel, Monserrat Villatoro Jaime, Marín-Serrano Eva, Stewart Stefan, Bardón Rivera Belén, Marín Jesús, Martínez de Soto Lucía, Seco Meseguer Enrique, Ramírez Elena

机构信息

Immunology Department La Paz-Cantoblanco-Carlos III University Hospital IdiPaz Madrid España.

Clinical Pharmacology Department Facultad de Medicina La Paz-Cantoblanco-Carlos III University Hospital IdiPaz Universidad Autónoma de Madrid Madrid España.

出版信息

Clin Case Rep. 2020 Sep 21;8(12):3105-3109. doi: 10.1002/ccr3.3348. eCollection 2020 Dec.

DOI:10.1002/ccr3.3348
PMID:33363890
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7752543/
Abstract

A 56-year-old female patient was hospitalized because of a lack of response and poor tolerance to multiple antidepressants, which included an episode of DILI. During hospitalization, the patient suffered another episode of DILI. Causality was assessed both by RUCAM and Lymphocyte Transformation Test, allowing to identify a safer medication.

摘要

一名56岁女性患者因对多种抗抑郁药反应不佳且耐受性差而住院，其中包括一次药物性肝损伤发作。住院期间，该患者又发生了一次药物性肝损伤发作。通过RUCAM和淋巴细胞转化试验评估因果关系，从而确定一种更安全的药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43a3/7752543/2ab17920912c/CCR3-8-3105-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43a3/7752543/2ab17920912c/CCR3-8-3105-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43a3/7752543/2ab17920912c/CCR3-8-3105-g001.jpg

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3
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