• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

微小RNA的治疗进展：临床前与临床最新情况

Therapeutic advances of miRNAs: A preclinical and clinical update.

作者信息

Chakraborty Chiranjib, Sharma Ashish Ranjan, Sharma Garima, Lee Sang-Soo

机构信息

Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Barasat-Barrackpore Rd, Kolkata, West Bengal 700126, India.

Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, Gangwon-Do 24252, Republic of Korea.

出版信息

J Adv Res. 2020 Aug 29;28:127-138. doi: 10.1016/j.jare.2020.08.012. eCollection 2021 Feb.

DOI:10.1016/j.jare.2020.08.012
PMID:33364050
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7753224/
Abstract

miRNAs, a class of small endogenous RNAs, are one of the essential biopharmaceuticals which are in commercial spans as next-generation medicine in recent times. A snapshot of the current scenario regarding the miRNAs as biopharmaceuticals have been discussed. In this work, biopharmaceutical companies working with miRNAs and the current status of preclinical/clinical trials about miRNA therapeutics have been reviewed. Finally, recent updates on the absorption, distribution, metabolism, and excretion (ADME), as well as a delivery system of miRNAs, have been illustrated.

摘要

微小RNA（miRNA）是一类小的内源性RNA，是近年来作为下一代药物进入商业领域的重要生物制药之一。本文讨论了有关miRNA作为生物制药的当前情况概述。在这项工作中，对致力于miRNA的生物制药公司以及miRNA疗法的临床前/临床试验现状进行了综述。最后，阐述了miRNA在吸收、分布、代谢和排泄（ADME）方面的最新进展以及miRNA的递送系统。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b63/7753224/7e6741d0eb25/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b63/7753224/072f51df92a7/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b63/7753224/d550054f9749/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b63/7753224/13bf8ff7503c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b63/7753224/7e6741d0eb25/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b63/7753224/072f51df92a7/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b63/7753224/d550054f9749/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b63/7753224/13bf8ff7503c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b63/7753224/7e6741d0eb25/gr3.jpg

相似文献

1
Therapeutic advances of miRNAs: A preclinical and clinical update.微小RNA的治疗进展：临床前与临床最新情况
J Adv Res. 2020 Aug 29;28:127-138. doi: 10.1016/j.jare.2020.08.012. eCollection 2021 Feb.
2
Therapeutic miRNA and siRNA: Moving from Bench to Clinic as Next Generation Medicine.治疗性微小RNA和小干扰RNA：作为新一代药物从实验室走向临床
Mol Ther Nucleic Acids. 2017 Sep 15;8:132-143. doi: 10.1016/j.omtn.2017.06.005. Epub 2017 Jun 12.
3
The Market of Biopharmaceutical Medicines: A Snapshot of a Diverse Industrial Landscape.生物制药市场：多元化产业格局概览。
Front Pharmacol. 2017 Jun 8;8:314. doi: 10.3389/fphar.2017.00314. eCollection 2017.
4
miRNAs: The Road from Bench to Bedside.miRNAs：从实验室到临床的转化之路。
Genes (Basel). 2023 Jan 25;14(2):314. doi: 10.3390/genes14020314.
5
MicroRNAs: synthesis, mechanism, function, and recent clinical trials.微小RNA：合成、机制、功能及近期临床试验
Biochim Biophys Acta. 2010 Nov;1803(11):1231-43. doi: 10.1016/j.bbamcr.2010.06.013. Epub 2010 Jul 7.
6
License Compliance Issues For Biopharmaceuticals: Special Challenges For Negotiations Between Companies And Non-Profit Research Institutions.生物制药的许可合规问题：公司与非营利性研究机构谈判面临的特殊挑战
LES Nouv. 2011 Sep 1;46(3):216-225.
7
Advances in MicroRNA Therapy for Heart Failure: Clinical Trials, Preclinical Studies, and Controversies.心力衰竭的微小RNA治疗进展：临床试验、临床前研究及争议
Cardiovasc Drugs Ther. 2025 Feb;39(1):221-232. doi: 10.1007/s10557-023-07492-7. Epub 2023 Jul 28.
8
Noncoding microRNAs: small RNAs play a big role in regulation of ADME?非编码微小RNA：小RNA在药物代谢动力学调节中发挥重要作用？
Acta Pharm Sin B. 2012 Apr;2(2):93-101. doi: 10.1016/j.apsb.2012.02.011. Epub 2012 Mar 31.
9
RNA-Based Therapeutics: From Antisense Oligonucleotides to miRNAs.基于 RNA 的治疗学：从反义寡核苷酸到 miRNA。
Cells. 2020 Jan 7;9(1):137. doi: 10.3390/cells9010137.
10
MicroRNAs in Liver Health and Disease.肝脏健康与疾病中的微小RNA
Curr Pathobiol Rep. 2013 Mar;1(1):53-62. doi: 10.1007/s40139-012-0005-4.

引用本文的文献

1
Human Umbilical Cord Blood Plasma-Derived Exosomal miR-410-3p Alleviates Liver Injury by Regulating the Mitochondria-Mediated Antiapoptotic Signaling.人脐带血血浆来源的外泌体miR-410-3p通过调节线粒体介导的抗凋亡信号减轻肝损伤。
MedComm (2020). 2025 Aug 24;6(9):e70339. doi: 10.1002/mco2.70339. eCollection 2025 Sep.
2
Treatment of KRAS-Mutated Pancreatic Cancer: New Hope for the Patients?KRAS 基因突变型胰腺癌的治疗：患者的新希望？
Cancers (Basel). 2025 Jul 24;17(15):2453. doi: 10.3390/cancers17152453.
3
Elevated miRNA-21, miRNA-155, and miRNA-182 levels correlate with cytokine dysregulation in neurological disorders and indicate potential for biomarker and therapy development.

本文引用的文献

1
Extracellular vesicle-mediated crosstalk between melanoma and the immune system: Impact on tumor progression and therapy response.细胞外囊泡介导的黑色素瘤与免疫系统间的串扰：对肿瘤进展和治疗反应的影响。
J Leukoc Biol. 2020 Oct;108(4):1101-1115. doi: 10.1002/JLB.3MR0320-644R. Epub 2020 May 25.
2
Beyond MicroRNAs: Emerging Role of Other Non-Coding RNAs in HPV-Driven Cancers.超越微小RNA：其他非编码RNA在人乳头瘤病毒驱动的癌症中的新作用
Cancers (Basel). 2020 May 15;12(5):1246. doi: 10.3390/cancers12051246.
3
Exosomal miR-21 promotes proliferation, invasion and therapy resistance of colon adenocarcinoma cells through its target PDCD4.
miRNA-21、miRNA-155和miRNA-182水平升高与神经疾病中的细胞因子失调相关，并提示其具有作为生物标志物和用于治疗开发的潜力。
Sci Rep. 2025 Jul 2;15(1):23523. doi: 10.1038/s41598-025-05372-8.
4
RNA Therapeutics: Focus on Antisense Oligonucleotides in the Nervous System.RNA疗法：聚焦于神经系统中的反义寡核苷酸
Biomol Ther (Seoul). 2025 Jun 19. doi: 10.4062/biomolther.2025.022.
5
Mitochondrial micro RNAs: Crucial players in carcinogenesis.线粒体微小RNA：癌症发生中的关键参与者。
Oncol Res. 2025 May 29;33(6):1301-1321. doi: 10.32604/or.2025.055945. eCollection 2025.
6
Therapeutic Applications of Poly-miRNAs and miRNA Sponges.多miRNA和miRNA海绵的治疗应用
Int J Mol Sci. 2025 May 9;26(10):4535. doi: 10.3390/ijms26104535.
7
Machine learning approaches for predicting the small molecule-miRNA associations: a comprehensive review.用于预测小分子与微小RNA关联的机器学习方法：全面综述
Mol Divers. 2025 May 20. doi: 10.1007/s11030-025-11211-9.
8
Mitochondrial microRNAs (mitomiRs) as emerging biomarkers and therapeutic targets for chronic human diseases.线粒体微小核糖核酸（线粒体miR）作为慢性人类疾病新出现的生物标志物和治疗靶点。
Front Genet. 2025 Apr 25;16:1555563. doi: 10.3389/fgene.2025.1555563. eCollection 2025.
9
The Role of microRNAs in Lung Cancer: Mechanisms, Diagnostics and Therapeutic Potential.微小RNA在肺癌中的作用：机制、诊断及治疗潜力
Int J Mol Sci. 2025 Apr 15;26(8):3736. doi: 10.3390/ijms26083736.
10
Connecting the Dots: How MicroRNAs Link Asthma and Atherosclerosis.连点成线：微小RNA如何将哮喘与动脉粥样硬化联系起来。
Int J Mol Sci. 2025 Apr 10;26(8):3570. doi: 10.3390/ijms26083570.
外泌体 miR-21 通过其靶基因 PDCD4 促进结肠腺癌细胞的增殖、侵袭和治疗抵抗。
Sci Rep. 2020 May 19;10(1):8271. doi: 10.1038/s41598-020-65207-6.
4
Combined loss of function of two different loci of miR-15/16 drives the pathogenesis of acute myeloid leukemia.两个不同 miR-15/16 基因座的功能丧失联合导致急性髓系白血病的发病机制。
Proc Natl Acad Sci U S A. 2020 Jun 2;117(22):12332-12340. doi: 10.1073/pnas.2003597117. Epub 2020 May 18.
5
Challenges identifying efficacious miRNA therapeutics for cancer.识别有效的癌症miRNA治疗方法面临的挑战。
Expert Opin Drug Discov. 2020 Sep;15(9):987-992. doi: 10.1080/17460441.2020.1765770. Epub 2020 May 18.
6
Nucleic acid nanotechnology for cancer treatment.核酸纳米技术在癌症治疗中的应用。
Biochim Biophys Acta Rev Cancer. 2020 Aug;1874(1):188377. doi: 10.1016/j.bbcan.2020.188377. Epub 2020 May 11.
7
The potential for microRNA-based therapeutics in retinal disorders.基于微小RNA的疗法在视网膜疾病中的潜力。
Ann Transl Med. 2020 Apr;8(7):419. doi: 10.21037/atm.2020.03.57.
8
Functional miRNA Screening Identifies Wide-ranging Antitumor Properties of miR-3622b-5p and Reveals a New Therapeutic Combination Strategy in Ovarian Tumor Organoids.功能 miRNA 筛选鉴定 miR-3622b-5p 的广泛抗肿瘤特性，并揭示卵巢肿瘤类器官中的新治疗联合策略。
Mol Cancer Ther. 2020 Jul;19(7):1506-1519. doi: 10.1158/1535-7163.MCT-19-0510. Epub 2020 May 5.
9
Advances in the discovery of microRNA-based anticancer therapeutics: latest tools and developments.基于 microRNA 的抗癌治疗药物的发现进展：最新工具和进展。
Expert Opin Drug Discov. 2020 Jan;15(1):63-83. doi: 10.1080/17460441.2020.1690449. Epub 2019 Nov 19.
10
MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside.微小 RNA 与结直肠癌的预后和治疗：从基础到临床。
World J Gastroenterol. 2018 Jul 21;24(27):2949-2973. doi: 10.3748/wjg.v24.i27.2949.