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甲状腺切除术中用于识别甲状旁腺的亚甲蓝喷雾剂

Methylene Blue Spray for Identification of Parathyroid Glands During Thyroidectomy.

作者信息

Monib Sherif, Mohamed Abdullah, Abdelaziz Mohamed I

机构信息

Breast Surgery, West Hertfordshire Hospitals NHS Trust, St Albans and Watford General Hospitals, London, GBR.

Surgery, Fayoum University Hospitals, Fayoum, EGY.

出版信息

Cureus. 2020 Nov 19;12(11):e11569. doi: 10.7759/cureus.11569.

DOI:10.7759/cureus.11569
PMID:33364096
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7749813/
Abstract

BACKGROUND

Hypocalcaemia is a common delayed complication after thyroidectomy. Several studies have identified risk factors and possible ways to prevent post-thyroidectomy hypocalcemia. The purpose of our study is to evaluate the effectiveness of an intraoperative methylene blue spray to identify parathyroid glands during thyroidectomy.

MATERIALS AND METHODS

We have conducted a prospective non-randomised cohort study with 50 patients who underwent hemithyroidectomy or total thyroidectomy between January 2019 and January 2020. During thyroidectomy, 1 ml (10 mg) of 1% methylene blue was sprayed over the parathyroid glands, the inferior thyroid artery, and the recurrent laryngeal nerve.

RESULTS

Our study included 50 patients with ages ranging from 18 to 80 years old (43.0±9.7). We were able to identify the parathyroid glands with the intraoperative methylene blue spray in 82% of cases, with no significant postoperative complications.

CONCLUSION

Our study concludes that the methylene blue spray is a safe, feasible, and effective technique to identify parathyroid glands.

摘要

背景

低钙血症是甲状腺切除术后常见的延迟并发症。多项研究已确定了危险因素以及预防甲状腺切除术后低钙血症的可能方法。我们研究的目的是评估术中使用亚甲蓝喷雾在甲状腺切除术中识别甲状旁腺的有效性。

材料与方法

我们进行了一项前瞻性非随机队列研究,研究对象为2019年1月至2020年1月期间接受半甲状腺切除术或全甲状腺切除术的50例患者。在甲状腺切除术中,将1毫升(10毫克)1%的亚甲蓝喷洒在甲状旁腺、甲状腺下动脉和喉返神经上。

结果

我们的研究纳入了50例年龄在18至80岁之间的患者(43.0±9.7)。在82%的病例中,我们能够通过术中亚甲蓝喷雾识别出甲状旁腺,且术后无明显并发症。

结论

我们的研究得出结论,亚甲蓝喷雾是一种安全、可行且有效的识别甲状旁腺的技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d11f/7749813/8091b5692fa1/cureus-0012-00000011569-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d11f/7749813/41fe65b7f2dd/cureus-0012-00000011569-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d11f/7749813/f9ea93acf8e8/cureus-0012-00000011569-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d11f/7749813/8091b5692fa1/cureus-0012-00000011569-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d11f/7749813/41fe65b7f2dd/cureus-0012-00000011569-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d11f/7749813/f9ea93acf8e8/cureus-0012-00000011569-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d11f/7749813/8091b5692fa1/cureus-0012-00000011569-i03.jpg

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本文引用的文献

1
Intraoperative optical coherence tomography imaging to identify parathyroid glands.术中光学相干断层扫描成像用于识别甲状旁腺。
Surg Endosc. 2015 Sep;29(9):2698-704. doi: 10.1007/s00464-014-3992-x. Epub 2014 Dec 5.
2
The value and role of low dose methylene blue in the surgical management of hyperparathyroidism.低剂量亚甲蓝在甲状旁腺功能亢进症手术治疗中的价值与作用
Ann R Coll Surg Engl. 2014 Oct;96(7):526-9. doi: 10.1308/003588414X13946184903883.
3
[Fine-needle aspiration with measurement of parathyroid hormone levels in thyroidectomy].
甲状腺癌手术:外科医生与甲状旁腺保留
J Clin Med. 2021 Sep 23;10(19):4323. doi: 10.3390/jcm10194323.
[甲状腺切除术中细针穿刺并测定甲状旁腺激素水平]
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Nov;48(11):934-8.
4
Safe thyroidectomy with intraoperative methylene blue spraying.术中喷洒亚甲蓝行安全甲状腺切除术
Thyroid Res. 2012 Nov 13;5(1):15. doi: 10.1186/1756-6614-5-15.
5
Intraoperative photodynamic detection of normal parathyroid glands using 5-aminolevulinic acid.术中使用 5-氨基酮戊酸进行正常甲状旁腺的光动力检测。
Laryngoscope. 2011 Jul;121(7):1462-6. doi: 10.1002/lary.21857. Epub 2011 Jun 6.
6
ON THE RELATION OF TETANY TO THE PARATHYROID GLANDS AND TO CALCIUM METABOLISM.论手足搐搦与甲状旁腺及钙代谢的关系。
J Exp Med. 1909 Jan 9;11(1):118-51. doi: 10.1084/jem.11.1.118.
7
Complications to thyroid surgery: results as reported in a database from a multicenter audit comprising 3,660 patients.甲状腺手术的并发症:多中心审计数据库中报告的3660例患者的结果。
Langenbecks Arch Surg. 2008 Sep;393(5):667-73. doi: 10.1007/s00423-008-0366-7. Epub 2008 Jul 17.
8
Frozen section of thyroid and parathyroid specimens.甲状腺和甲状旁腺标本的冰冻切片。
Arch Pathol Lab Med. 2005 Dec;129(12):1575-84. doi: 10.5858/2005-129-1575-FSOTAP.
9
Prospective study of postoperative complications after total thyroidectomy for multinodular goiters by surgeons with experience in endocrine surgery.由内分泌外科经验丰富的外科医生对多结节性甲状腺肿行全甲状腺切除术后并发症进行的前瞻性研究。
Ann Surg. 2004 Jul;240(1):18-25. doi: 10.1097/01.sla.0000129357.58265.3c.
10
The history of parathyroid surgery, 1850-1996: the Excelsior Surgical Society 1998 Edward D Churchill Lecture.甲状旁腺手术史,1850 - 1996年:卓越外科学会1998年爱德华·D·丘吉尔讲座
J Am Coll Surg. 2000 Sep;191(3):284-99. doi: 10.1016/s1072-7515(00)00347-1.