人乳头瘤病毒在鼻窦鳞状细胞癌中的预后意义。
The prognostic significance of human papilloma virus in sinonasal squamous cell carcinoma.
作者信息
Schlussel Markovic Emily, Marqueen Kathryn E, Sindhu Kunal K, Lehrer Eric J, Liu Jerry, Miles Brett, Genden Eric, Sharma Sonam, Gupta Vishal, Westra William, Iloreta Alfred, Posner Marshall, Misiukiewicz Krzysztof, Bakst Richard L
机构信息
Department of Radiation Oncology Icahn School of Medicine at Mount Sinai New York New York USA.
Department of Otolaryngology Icahn School of Medicine at Mount Sinai New York New York USA.
出版信息
Laryngoscope Investig Otolaryngol. 2020 Nov 4;5(6):1070-1078. doi: 10.1002/lio2.468. eCollection 2020 Dec.
BACKGROUND
Human papilloma virus (HPV) has been implicated in the pathology of oropharyngeal head and neck cancers, but its role in sinonasal squamous cell carcinoma (SNSCC) has not been well established.
METHODS
Thirty-two patients with SNSCC diagnosed between 2011 and 2018 were identified and stratified by HPV status and viral serotype, as determined by PCR. Endpoints including recurrence, metastases and survival were analyzed using the Kaplan-Meier method.
RESULTS
Seventeen (53%) patients were HPV-positive and 15 (47%) were HPV-negative. The median follow-up time of living patients was 30.7 months (range 4-123 months). Survival did not differ by HPV status, but HPV+ tumors were more likely to locally recur and metastasize. When stratifying by treatment type, the lowest rate of recurrence occurred in patients receiving surgery and chemoradiation.
CONCLUSION
A significant proportion of sinonasal tumors appear to be associated with HPV. Testing for HPV might be justified in all cases of sinonasal cancers. Further investigation is warranted to better understand the role of HPV in SNSCC.
背景
人乳头瘤病毒（HPV）与口咽头颈癌的病理过程有关，但其在鼻窦鳞状细胞癌（SNSCC）中的作用尚未完全明确。
方法
纳入2011年至2018年间确诊的32例SNSCC患者，根据PCR检测确定的HPV状态和病毒血清型进行分层。采用Kaplan-Meier法分析包括复发、转移和生存在内的终点指标。
结果
17例（53%）患者HPV阳性，15例（47%）患者HPV阴性。存活患者的中位随访时间为30.7个月（范围4 - 123个月）。生存情况在HPV状态方面无差异，但HPV阳性肿瘤更易局部复发和转移。按治疗类型分层时，接受手术加放化疗的患者复发率最低。
结论
相当一部分鼻窦肿瘤似乎与HPV有关。对所有鼻窦癌病例进行HPV检测可能是合理的。有必要进一步研究以更好地了解HPV在SNSCC中的作用。
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