Chatterjee S N, Terasaki P I, Fine S, Schulman B, Smith R, Fine R N
Surg Gynecol Obstet. 1977 Nov;145(5):729-32.
Fifty cadaveric kidney donors were randomly allocated to two groups. Group 1 received 5 grams of intravenously administered methylprednisolone two to four hours prior to organ harvesting after the pronouncement of brain death. Group 2, which served as the control group, received no pretreatment. Of 100 kidneys harvested, 16 were discarded for various reasons, and 84 were transplanted and were available for evaluation, 40 from the pretreatment group and 44 from the control group. The transplant centers using these kidneys were unaware of the status of the kidney they received, that is, whether it was from a pretreated or a control group. The two groups of kidneys, pretreated and control, did not differ according to the length of warm or cold ischemia time or presence of preformed cytotoxic antibodies. The difference in graft failure between the two groups at three months was insignificant, even when the two groups were compared according to the method of preservation used.
五十名尸体肾供体被随机分为两组。第一组在脑死亡宣告后、器官获取前两到四小时静脉注射5克甲基强的松龙。第二组作为对照组，未接受预处理。在获取的100个肾脏中，16个因各种原因被丢弃，84个被移植并可供评估，其中40个来自预处理组，44个来自对照组。使用这些肾脏的移植中心不知道他们所接收肾脏的状态，即它是来自预处理组还是对照组。预处理组和对照组的两组肾脏在热缺血或冷缺血时间长短或是否存在预先形成的细胞毒性抗体方面没有差异。即使根据所使用的保存方法对两组进行比较，两组在三个月时移植物失败的差异也不显著。
