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Sustained virological response after treatment with direct-acting antivirals can help immune reconstitution in HIV-HCV coinfected patients even in case of persistent HIV low-level viremia.即使在持续性HIV低水平病毒血症的情况下，直接抗病毒药物治疗后的持续病毒学应答也有助于HIV-HCV合并感染患者的免疫重建。
Health Sci Rep. 2020 Dec 21;4(1):e221. doi: 10.1002/hsr2.221. eCollection 2021 Mar.
2
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Human Immunodeficiency Virus (HIV) Infection Is Associated With Lower Risk of Hepatocellular Carcinoma After Sustained Virological Response to Direct-acting Antivirals in Hepatitis C Infected Patients With Advanced Fibrosis.在丙型肝炎感染且伴有严重肝纤维化的患者中，对直接抗病毒药物产生持续病毒学应答后，人类免疫缺陷病毒（HIV）感染与肝细胞癌风险降低相关。
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Impact of CD4+ blood cell count and HIV viral load on treatment response with direct acting antivirals in HIV and HCV coinfected patients: insights from the German Hepatitis C-Registry.CD4 +血细胞计数和HIV病毒载量对HIV与HCV合并感染患者直接抗病毒药物治疗反应的影响：来自德国丙型肝炎登记处的见解
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Direct-acting antivirals in hepatitis C virus (HCV)-infected and HCV/HIV-coinfected patients: real-life safety and efficacy.丙型肝炎病毒（HCV）感染及HCV/人类免疫缺陷病毒（HIV）合并感染患者中直接抗病毒药物的真实安全性和疗效
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Liver function following hepatitis C virus eradication by direct acting antivirals in patients with liver cirrhosis: data from the PITER cohort.直接作用抗病毒药物清除丙型肝炎病毒后肝硬化患者的肝功能：来自 PITER 队列的数据。
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Sustained virological response at week 12 after interferon-free therapy as criterion for HCV cure definition: Validation in a real-life cohort of HIV-coinfected patients.无干扰素治疗后第 12 周的持续病毒学应答作为 HCV 治愈定义的标准：在 HIV 合并感染患者的真实队列中的验证。
Enferm Infecc Microbiol Clin (Engl Ed). 2020 Jun-Jul;38(6):275-278. doi: 10.1016/j.eimc.2019.07.009. Epub 2019 Oct 24.
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Long-term evolution in liver disease markers and immune and lipid profiles in vertically HIV/HCV-coinfected youths with sustained viral response after direct-acting antivirals therapy.接受直接抗病毒治疗后病毒得到持续抑制的垂直感染艾滋病毒/丙型肝炎病毒的青年患者，其肝病标志物、免疫和血脂指标的长期演变情况
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Liver Stiffness-Based Strategies Predict Absence of Variceal Bleeding in Cirrhotic Hepatitis C Virus-Infected Patients With and Without Human Immunodeficiency Virus Coinfection After Sustained Virological Response.基于肝硬度的策略预测 HCV 肝硬化合并 HIV 感染患者获得持续病毒学应答后是否发生静脉曲张出血。
Clin Infect Dis. 2021 Mar 1;72(5):e96-e102. doi: 10.1093/cid/ciaa1726.

本文引用的文献

1
Variation in estimated viral suppression associated with the definition of viral suppression used.定义病毒抑制的不同会导致所估计的病毒抑制率存在差异。
AIDS. 2020 Aug 1;34(10):1519-1526. doi: 10.1097/QAD.0000000000002579.
2
Effect on the adherence to concomitant medications after initiation of treatment with direct-acting antiviral agents against hepatitis C virus.直接作用抗病毒药物治疗丙型肝炎病毒后对伴随药物治疗依从性的影响。
Gastroenterol Hepatol. 2020 Oct;43(8):418-425. doi: 10.1016/j.gastrohep.2020.02.011. Epub 2020 Apr 9.
3
All-Cause Mortality and Serious Non-AIDS Events in Adults With Low-level Human Immunodeficiency Virus Viremia During Combination Antiretroviral Therapy: Results From a Swedish Nationwide Observational Study.在接受联合抗逆转录病毒治疗期间，人类免疫缺陷病毒低病毒血症成人的全因死亡率和严重非艾滋病事件：来自瑞典全国观察性研究的结果。
Clin Infect Dis. 2021 Jun 15;72(12):2079-2086. doi: 10.1093/cid/ciaa413.
4
Hepatitis C Virus Cure in Human Immunodeficiency Virus Coinfection Dampens Inflammation and Improves Cognition Through Multiple Mechanisms.丙型肝炎病毒治愈在人类免疫缺陷病毒合并感染中通过多种机制抑制炎症和改善认知。
J Infect Dis. 2020 Jul 6;222(3):396-406. doi: 10.1093/infdis/jiaa109.
5
HIV/HCV therapy with ledipasvir/sofosbuvir after randomized switch to emtricitabine-tenofovir alafenamide-based single-tablet regimens.接受 ledipasvir/sofosbuvir 治疗的 HIV/HCV 患者随机转换为恩曲他滨/替诺福韦艾拉酚胺单片复方制剂治疗。
PLoS One. 2020 Jan 29;15(1):e0224875. doi: 10.1371/journal.pone.0224875. eCollection 2020.
6
Impact of HCV eradication with direct-acting antiviral agents on serum gamma globulin levels in HCV and HCV/HIV coinfected patients.直接作用抗病毒药物清除 HCV 对 HCV 和 HCV/HIV 合并感染患者血清球蛋白水平的影响。
Eur J Intern Med. 2020 May;75:50-54. doi: 10.1016/j.ejim.2020.01.006. Epub 2020 Jan 21.
7
Naïve/Effector CD4 T cell ratio as a useful predictive marker of immune reconstitution in late presenter HIV patients: A multicenter study.幼稚/效应性 CD4 T 细胞比值可作为晚期 HIV 患者免疫重建的有用预测标志物：一项多中心研究。
PLoS One. 2019 Dec 23;14(12):e0225415. doi: 10.1371/journal.pone.0225415. eCollection 2019.
8
Evaluation of Safety and Effectiveness of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Switch Followed by Ledipasvir/Sofosbuvir HCV Therapy in HIV-HCV Coinfection.评估埃替拉韦/考比司他/恩曲他滨/替诺福韦艾拉酚胺转换后再接受来迪派韦/索磷布韦丙肝治疗方案在HIV-HCV合并感染患者中的安全性和有效性。
Open Forum Infect Dis. 2019 Jul 1;6(7). doi: 10.1093/ofid/ofz318.
9
Low-level viremia and virologic failure in persons with HIV infection treated with antiretroviral therapy.接受抗逆转录病毒治疗的 HIV 感染者的低水平病毒血症和病毒学失败。
AIDS. 2019 Nov 1;33(13):2005-2012. doi: 10.1097/QAD.0000000000002306.
10
Influence of Hepatitis C virus coinfection on immune reconstitution in HIV subjects.丙型肝炎病毒合并感染对 HIV 感染者免疫重建的影响。
Med Microbiol Immunol. 2019 Dec;208(6):747-756. doi: 10.1007/s00430-019-00619-4. Epub 2019 May 30.

Sustained virological response after treatment with direct-acting antivirals can help immune reconstitution in HIV-HCV coinfected patients even in case of persistent HIV low-level viremia.

作者信息

Basso Monica, Zago Daniela, Pozzetto Irene, Battagin Giuliana, Carlotto Antonio, Rossi Maria Cristina, Panese Sandro, Sarmati Loredana, Parisi Saverio Giuseppe

机构信息

Department of Molecular Medicine University of Padova Padova Italy.

Clinical Infectious Diseases Vicenza Hospital Vicenza Italy.

出版信息

Health Sci Rep. 2020 Dec 21;4(1):e221. doi: 10.1002/hsr2.221. eCollection 2021 Mar.

DOI:10.1002/hsr2.221
PMID:33364441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7752158/
Abstract
摘要