Sustained virological response after treatment with direct-acting antivirals can help immune reconstitution in HIV-HCV coinfected patients even in case of persistent HIV low-level viremia.
作者信息
Basso Monica, Zago Daniela, Pozzetto Irene, Battagin Giuliana, Carlotto Antonio, Rossi Maria Cristina, Panese Sandro, Sarmati Loredana, Parisi Saverio Giuseppe
机构信息
Department of Molecular Medicine University of Padova Padova Italy.
Clinical Infectious Diseases Vicenza Hospital Vicenza Italy.
出版信息
Health Sci Rep. 2020 Dec 21;4(1):e221. doi: 10.1002/hsr2.221. eCollection 2021 Mar.
Abstract
摘要
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Sustained virological response after treatment with direct-acting antivirals can help immune reconstitution in HIV-HCV coinfected patients even in case of persistent HIV low-level viremia.即使在持续性HIV低水平病毒血症的情况下，直接抗病毒药物治疗后的持续病毒学应答也有助于HIV-HCV合并感染患者的免疫重建。
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本文引用的文献
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Variation in estimated viral suppression associated with the definition of viral suppression used.定义病毒抑制的不同会导致所估计的病毒抑制率存在差异。
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Effect on the adherence to concomitant medications after initiation of treatment with direct-acting antiviral agents against hepatitis C virus.直接作用抗病毒药物治疗丙型肝炎病毒后对伴随药物治疗依从性的影响。
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All-Cause Mortality and Serious Non-AIDS Events in Adults With Low-level Human Immunodeficiency Virus Viremia During Combination Antiretroviral Therapy: Results From a Swedish Nationwide Observational Study.在接受联合抗逆转录病毒治疗期间，人类免疫缺陷病毒低病毒血症成人的全因死亡率和严重非艾滋病事件：来自瑞典全国观察性研究的结果。
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4
Hepatitis C Virus Cure in Human Immunodeficiency Virus Coinfection Dampens Inflammation and Improves Cognition Through Multiple Mechanisms.丙型肝炎病毒治愈在人类免疫缺陷病毒合并感染中通过多种机制抑制炎症和改善认知。
J Infect Dis. 2020 Jul 6;222(3):396-406. doi: 10.1093/infdis/jiaa109.
5
HIV/HCV therapy with ledipasvir/sofosbuvir after randomized switch to emtricitabine-tenofovir alafenamide-based single-tablet regimens.接受 ledipasvir/sofosbuvir 治疗的 HIV/HCV 患者随机转换为恩曲他滨/替诺福韦艾拉酚胺单片复方制剂治疗。
PLoS One. 2020 Jan 29;15(1):e0224875. doi: 10.1371/journal.pone.0224875. eCollection 2020.
6
Impact of HCV eradication with direct-acting antiviral agents on serum gamma globulin levels in HCV and HCV/HIV coinfected patients.直接作用抗病毒药物清除 HCV 对 HCV 和 HCV/HIV 合并感染患者血清球蛋白水平的影响。
Eur J Intern Med. 2020 May;75:50-54. doi: 10.1016/j.ejim.2020.01.006. Epub 2020 Jan 21.
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Naïve/Effector CD4 T cell ratio as a useful predictive marker of immune reconstitution in late presenter HIV patients: A multicenter study.幼稚/效应性 CD4 T 细胞比值可作为晚期 HIV 患者免疫重建的有用预测标志物：一项多中心研究。
PLoS One. 2019 Dec 23;14(12):e0225415. doi: 10.1371/journal.pone.0225415. eCollection 2019.
8
Evaluation of Safety and Effectiveness of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Switch Followed by Ledipasvir/Sofosbuvir HCV Therapy in HIV-HCV Coinfection.评估埃替拉韦/考比司他/恩曲他滨/替诺福韦艾拉酚胺转换后再接受来迪派韦/索磷布韦丙肝治疗方案在HIV-HCV合并感染患者中的安全性和有效性。
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Low-level viremia and virologic failure in persons with HIV infection treated with antiretroviral therapy.接受抗逆转录病毒治疗的 HIV 感染者的低水平病毒血症和病毒学失败。
AIDS. 2019 Nov 1;33(13):2005-2012. doi: 10.1097/QAD.0000000000002306.
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Influence of Hepatitis C virus coinfection on immune reconstitution in HIV subjects.丙型肝炎病毒合并感染对 HIV 感染者免疫重建的影响。
Med Microbiol Immunol. 2019 Dec;208(6):747-756. doi: 10.1007/s00430-019-00619-4. Epub 2019 May 30.
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