Zhou Yingyu, Takano Tomohiro, Wang Yimei, Li Xuyang, Wang Rong, Wakatsuki Yoshio, Nakajima-Adachi Haruyo, Tanokura Masaru, Miyakawa Takuya, Hachimura Satoshi
Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
iScience. 2020 Nov 30;24(1):101883. doi: 10.1016/j.isci.2020.101883. eCollection 2021 Jan 22.
The role of the intestinal immune system in the inhibition of fat tissue-related inflammation by dietary material is yet to be elucidated. Oral administration of β-elemene, contained in various foodstuffs, downregulated expressions of inflammatory cytokines and increased Foxp3CD4 T cells in adipose tissue of obese mice. However, β-elemene did not affect the inflammatory response of adipose tissue , suggesting that the inhibition observed was not due to direct interactions of adipose tissue with β-elemene. Instead, β-elemene increased Foxp3CD4 T cell population enhancing gene expressions of transforming growth factor β 1, retinaldehyde dehydrogenase 2, integrin αvβ8, and interleukin-10 in intestinal dendritic cells (DCs) and . Taken together, this study suggested the therapeutic effects of β-elemene on treating experimental obesity-induced chronic inflammation by adjusting the balance of immune cell populations in fat tissue through the generation of regulatory T cells in the intestinal immune system by modulating DC function.
肠道免疫系统在膳食物质抑制脂肪组织相关炎症中所起的作用尚待阐明。多种食物中含有的β-榄香烯经口服后，可下调肥胖小鼠脂肪组织中炎性细胞因子的表达，并增加Foxp3 CD4 T细胞。然而，β-榄香烯并未影响脂肪组织的炎症反应，这表明所观察到的抑制作用并非源于脂肪组织与β-榄香烯的直接相互作用。相反，β-榄香烯增加了Foxp3 CD4 T细胞群体，增强了肠道树突状细胞（DCs）中转化生长因子β1、视黄醛脱氢酶2、整合素αvβ8和白细胞介素-10的基因表达。综上所述，本研究表明，β-榄香烯可通过调节DC功能，在肠道免疫系统中生成调节性T细胞，从而调整脂肪组织中免疫细胞群体的平衡，对治疗实验性肥胖诱导的慢性炎症具有治疗作用。
