Simsek Gulsum Kadioglu, Kutman H Gozde Kanmaz, Canpolat Fuat Emre
Department of Neonatology, University of Health Sciences Turkey, Zekai Tahir Burak Women's Health Practice and Research Center Hospital, Ankara, Turkey.
Sisli Etfal Hastan Tip Bul. 2020 Dec 11;54(4):433-437. doi: 10.14744/SEMB.2019.68916. eCollection 2020.
We assessed the effects of antenatal steroid treatment on preterm laboratory analysis conducted in the first 24 hours of life.
Medical records of inborn preterm infants whose gestational age was ≤32 weeks were retrospectively reviewed in this study. Preterm infants whose mothers received antenatal betamethasone treatment of either 12 mg or 24 mg and who did not were divided into two groups. Maternal and neonatal demographic characteristics, all preterm morbidities and mortality rates, early laboratory examinations were compared between the two groups.
Medical records of 603 infants between 2008 and 2013 were retrospectively reviewed. Data from 515 infants were analyzed. Three hundred and four infants (n=304) were in the antenatal steroid treatment (AST) group and 211 infants were in the group that did not receive the treatment. The incidence of preeclampsia and oligohydramnios was significantly higher in the AST group. Intubation in the delivery room rates decreased in the AST group. APGAR scores at five minutes were significantly higher in the AST group. White blood counts (WBC) significantly decreased, whereas the platelet counts were higher in the AST group. Serum C-reactive protein (CRP) and Interleukin-6 (IL-6) levels did not differ between groups.
We did not demonstrate any relationship between inflammatory markers and antenatal steroid treatment in preterm infants.
我们评估了产前类固醇治疗对出生后24小时内进行的早产实验室分析的影响。
本研究回顾性分析了胎龄≤32周的早产儿的病历。母亲接受12毫克或24毫克产前倍他米松治疗的早产儿和未接受治疗的早产儿被分为两组。比较两组的母婴人口统计学特征、所有早产发病率和死亡率以及早期实验室检查结果。
回顾性分析了2008年至2013年间603例婴儿的病历。分析了515例婴儿的数据。304例婴儿（n = 304）在产前类固醇治疗（AST）组，211例婴儿在未接受治疗组。AST组先兆子痫和羊水过少的发生率显著更高。AST组产房插管率降低。AST组5分钟时的阿氏评分显著更高。AST组白细胞计数（WBC）显著降低，而血小板计数更高。两组间血清C反应蛋白（CRP）和白细胞介素-6（IL-6）水平无差异。
我们未发现早产儿炎症标志物与产前类固醇治疗之间存在任何关联。
