Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Early Hum Dev. 2011 Aug;87(8):559-64. doi: 10.1016/j.earlhumdev.2011.04.013. Epub 2011 May 14.
To evaluate the effect of maternal administration of antenatal steroids (ANS) on cord blood cytokine levels at birth in preterm infants.
Cord blood cytokine concentrations were measured for pro-inflammatory cytokines (IL-1β, IL-6, and IL-8); anti-inflammatory cytokines (IL-4, IL-10 and TGF-β); and neurotrophic cytokines (BDNF, NT-3, and NT-4) in two hundred preterm infants. Data were analyzed using multivariable linear regression to model the independent and joint effects of ANS and inflammation on mean log cord blood cytokine concentrations adjusted for gestational age and Apgar scores.
Exposure to ANS had no significant effect on the cord blood concentrations of cytokines measured in this study. All three pro-inflammatory cytokine levels and levels of IL-10 were significantly increased and cord blood levels of TGF-β and NT-3 were significantly decreased in infants with placental inflammation.
Although exposure to ANS did not have any significant effect on cord blood levels of cytokines, there was a trend toward the attenuation of inflammatory response and higher levels of neurotrophic cytokines in infants born to mothers with placental inflammation and exposure to ANS compared to infants born to mothers with placental inflammation and no ANS exposure.
评估产前给予皮质类固醇（ANS）对早产儿出生时脐血细胞因子水平的影响。
对 200 例早产儿的促炎细胞因子（IL-1β、IL-6 和 IL-8）、抗炎细胞因子（IL-4、IL-10 和 TGF-β）和神经营养细胞因子（BDNF、NT-3 和 NT-4）的脐血细胞因子浓度进行了测量。采用多变量线性回归分析来模拟 ANS 和炎症对调整胎龄和 Apgar 评分后的平均对数脐血细胞因子浓度的独立和联合影响。
接触 ANS 对本研究中测量的细胞因子的脐血浓度没有显著影响。在胎盘炎症的婴儿中，三种促炎细胞因子水平和 IL-10 水平显著升高，而 TGF-β 和 NT-3 的脐血水平显著降低。
尽管接触 ANS 对脐血细胞因子水平没有显著影响，但与胎盘炎症且未接触 ANS 的婴儿相比，胎盘炎症且接触 ANS 的婴儿的炎症反应呈减弱趋势，神经营养细胞因子水平较高。
