Green J E, Dorfmann A, Jones S L, Bender S, Patton L, Schulman J D
Genetics & IVF Institute, Fairfax, Virginia.
Obstet Gynecol. 1988 Feb;71(2):208-12.
Of over 1000 patients referred to the Genetics & IVF Institute for chorionic villus sampling, 10% had an abnormal gestational sac at the time of initial presentation. Villus sampling could not be performed in 0.6% of cases, usually because of fibroids. Chorioamnionitis, probably related to the procedure, occurred in two patients (0.2%). The total fetal loss was 2.4%, which is not significantly different from the background fetal loss rate reported in normal pregnancies after eight weeks of gestation. The procedure-related loss was estimated as approximately 0.6%. The cytogenetic analysis routinely used was "direct" trophoblast karyotyping. There were no false-negative diagnoses. Trophoblastic mosaicism was observed in 1.3% of samples. Amniocentesis was performed in 3.5% of cases because of chorionic villus sampling failure, chorionic mosaicism, or elevated maternal serum alpha-fetoprotein (MSAFP) concentrations. Chorionic villus sampling was not associated with falsely elevated MSAFP levels at 15-18 weeks' gestation. Chorionic villus sampling has proved a safe and accurate prenatal diagnostic method associated with relatively low risk when performed by an experienced team, although additional amniocentesis will be necessary in a small percentage of pregnancies.
在转诊至遗传与试管婴儿研究所进行绒毛取样的1000多名患者中，10%在初次就诊时孕囊异常。0.6%的病例无法进行绒毛取样，通常是由于子宫肌瘤。两名患者（0.2%）发生了可能与该操作相关的绒毛膜羊膜炎。总胎儿丢失率为2.4%，与妊娠8周后正常妊娠报道的背景胎儿丢失率无显著差异。与操作相关的丢失估计约为0.6%。常规使用的细胞遗传学分析是“直接”滋养层核型分析。没有假阴性诊断。1.3%的样本中观察到滋养层嵌合体。3.5%的病例因绒毛取样失败、绒毛嵌合体或孕妇血清甲胎蛋白（MSAFP）浓度升高而进行了羊膜穿刺术。绒毛取样与妊娠15 - 18周时MSAFP水平假性升高无关。绒毛取样已被证明是一种安全、准确的产前诊断方法，由经验丰富的团队进行时风险相对较低，但在一小部分妊娠中仍需要额外进行羊膜穿刺术。
