Linsell M, Jablonski P, Howden B, Scott D, Marshall V
Monash University Department of Surgery, Prince Henry's Hospital, Melbourne, Australia.
Plast Reconstr Surg. 1988 Feb;81(2):240-5.
A new experimental model for free-flap transfer has been developed in the rat. This "thigh flap" is an osteomyocutaneous free flap of bone (femur), muscle (thigh), and skin (groin) based on the femoral vessels. The flap is harvested from the left groin and thigh of an inbred female rat and is transferred to a subcutaneous pocket in the left groin of a male rat of the same inbred strain. The femoral vessels supplying the flap are anastomosed end-to-end with the femoral vessels of the recipient. Thirty flaps have been transferred, with 5 technical failures. Three of the remaining 25 flaps developed necrosis within 24 hours. The other 22 flaps remained viable until the rat was sacrificed at 7 days. The survival rate of the thigh flap was thus 88 percent. The model is suitable for use in metabolic, vascular, and immunologic studies of composite free flaps.
已在大鼠身上开发出一种新的游离皮瓣移植实验模型。这种“大腿皮瓣”是一种基于股血管的骨（股骨）、肌肉（大腿）和皮肤（腹股沟）的骨肌皮游离皮瓣。该皮瓣取自近交系雌性大鼠的左腹股沟和大腿，并转移至同一近交系雄性大鼠左腹股沟的皮下囊袋中。供应皮瓣的股血管与受体的股血管端端吻合。已进行了30次皮瓣移植，其中5次技术失败。其余25个皮瓣中有3个在24小时内发生坏死。另外22个皮瓣在大鼠7天时处死前一直存活。因此，大腿皮瓣的存活率为88%。该模型适用于复合游离皮瓣的代谢、血管和免疫学研究。
