Marcucci Carolina, Relats Juan Manuel Anselmi, Bach Hernán G, Kamecki Fabiola, Varela Beatriz G, Wagner Marcelo L, Pastore Valentina, Colettis Natalia, Ricco Rafael A, Marder Mariel
Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini, Facultad de Farmacia y Bioquímica, Junín 956 (C1113AAD), Buenos Aires, Argentina.
Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Farmacología, Cátedra de Farmacobotánica, Buenos Aires, Argentina.
Heliyon. 2020 Dec 14;6(12):e05691. doi: 10.1016/j.heliyon.2020.e05691. eCollection 2020 Dec.
Folkloric or galenic preparations of valerian roots and rhizomes have been used as sedatives/anxiolytics and sleep inducers since ancient times. "Valerianas" are plants that naturally grow in our region. Although some of them are used in folk medicine, they lack scientific information. We performed a comparative study of the phytochemical composition and the potential effects of ethanolic extracts of argentine valerian species: Sm Phil. and Poepp. ex DC., from "Patagonia Argentina"; (Griseb.) Höck and Griseb., from the central part of our country, and (as the reference plant). All these plants were rich in phenolic compounds, evidenced the presence of ligands for the benzodiazepine binding site of the GABA receptor and were able to induce sedation as assessed by loss-of-righting reflex assays (500 mg/kg, i.p.). Mice treated with , and extracts showed reduced exploratory behaviors while produced anxiolytic-like activities (500 mg/kg, i.p.) in the Hole board test. Oral administrations (300 mg/kg and 600 mg/kg, p.o.) evidenced sedative effects for and anxiolytic-like properties for , and extracts. Our native valerian species are active on the CNS, validating its folkloric use as anxiolytic/sedative and sleep enhancers.
自古以来，缬草根和根茎的民间制剂或草药制剂就被用作镇静剂/抗焦虑药和助眠剂。“缬草属植物”是自然生长在我们地区的植物。虽然其中一些被用于民间医学，但它们缺乏科学依据。我们对阿根廷缬草属物种乙醇提取物的植物化学成分和潜在作用进行了比较研究：来自“阿根廷巴塔哥尼亚”的Sm Phil.和Poepp. ex DC.；来自我国中部的(Griseb.) Höck和Griseb.，以及（作为参考植物）。所有这些植物都富含酚类化合物，证明存在GABA受体苯二氮䓬结合位点的配体，并且通过翻正反射试验（500mg/kg，腹腔注射）评估能够诱导镇静作用。用、和提取物处理的小鼠表现出探索行为减少，而在旷场试验中（500mg/kg，腹腔注射）产生了抗焦虑样活性。口服给药（300mg/kg和600mg/kg，口服）证明对有镇静作用，对、和提取物有抗焦虑样特性。我们本土的缬草属物种对中枢神经系统有活性，证实了其在民间作为抗焦虑/镇静剂和睡眠增强剂的用途。
