Weissleder R, Stark D D, Rummeny E J, Compton C C, Ferrucci J T
Department of Radiology, Massachusetts General Hospital, Boston 02114.
Radiology. 1988 Feb;166(2):423-30. doi: 10.1148/radiology.166.2.3336717.
Ferrite, a new magnetic resonance (MR) contrast agent, was evaluated in the detection and diagnosis of splenic lymphoma. Before administration of ferrite, normal rat spleens and spleens with diffuse lymphoma showed similar in vitro relaxation times and in vivo MR imaging signal-to-noise ratios (S/N). After the administration of ferrite (50 mumol Fe/kg), the T2 time of lymphomatous spleen was 27.0 msec +/- 2.9 (mean +/- standard deviation), which was significantly greater than that of normal spleen (10.7 msec +/- 1.5, P less than .005). The S/N of ferrite-enhanced in vivo MR images of lymphomatous spleen was 12.4 +/- 0.9, which was significantly greater than normal (5.7 +/- 0.2, P less than .005). Similar experiments with animal models of micronodular lymphoma also demonstrated that ferrite-enhanced MR imaging can distinguish micronodular lymphoma from normal spleen. Benign splenomegaly, studied with an animal model of erythroid hyperplasia, showed ferrite-enhanced MR tissue characteristics that were indistinguishable from those of normal spleen.
铁氧体是一种新型磁共振（MR）造影剂，对其在脾脏淋巴瘤检测和诊断中的应用进行了评估。在给予铁氧体之前，正常大鼠脾脏和弥漫性淋巴瘤脾脏在体外弛豫时间和体内MR成像信噪比（S/N）方面表现相似。给予铁氧体（50 μmol Fe/kg）后，淋巴瘤脾脏的T2时间为27.0毫秒±2.9（平均值±标准差），显著长于正常脾脏（10.7毫秒±1.5，P<0.005）。淋巴瘤脾脏的铁氧体增强体内MR图像的S/N为12.4±0.9，显著高于正常脾脏（5.7±0.2，P<0.005）。对微结节性淋巴瘤动物模型进行的类似实验也表明，铁氧体增强MR成像可将微结节性淋巴瘤与正常脾脏区分开来。用红细胞增生动物模型研究的良性脾肿大显示，铁氧体增强的MR组织特征与正常脾脏无法区分。
