Tsang Y M, Stark D D, Chen M C, Weissleder R, Wittenberg J, Ferrucci J T
Medical College and Hospital, National Taiwan University, Taipei, Republic of China.
Radiology. 1988 Apr;167(1):21-4. doi: 10.1148/radiology.167.1.3347724.
A rat tumor model was used to evaluate the ability of ferrite-enhanced magnetic resonance (MR) imaging to demonstrate hepatic metastases smaller than 1 cm. Twenty-eight rat livers were inoculated with 5 X 10(5) mammary carcinoma cells and imaged with a 0.6-T MR system. Non-enhanced and ferrite-enhanced images were analyzed and correlated with autopsy findings for each rat. Lesion detection rates correlated closely with cancer-to-liver contrast-to-noise ratios. Ferrite-enhanced MR imaging demonstrated significantly more lesions than non-enhanced imaging (P less than .05) and decreased the threshold size for lesion detectability (less than 2 mm). Ferrite also enabled more accurate measurements of the lesions (r = .96).
采用大鼠肿瘤模型评估铁氧体增强磁共振（MR）成像显示小于1 cm肝转移灶的能力。给28只大鼠肝脏接种5×10⁵个乳腺癌细胞，并用0.6-T MR系统进行成像。分析未增强和铁氧体增强图像，并与每只大鼠的尸检结果进行对比。病灶检测率与癌-肝对比噪声比密切相关。铁氧体增强MR成像显示的病灶明显多于未增强成像（P<0.05），并降低了病灶可检测性的阈值大小（小于2 mm）。铁氧体还能更准确地测量病灶（r = 0.96）。
