Saini S, Stark D D, Hahn P F, Bousquet J C, Introcasso J, Wittenberg J, Brady T J, Ferrucci J T
Radiology. 1987 Jan;162(1 Pt 1):217-22. doi: 10.1148/radiology.162.1.3786766.
The potential of superparamagnetic ferrite particles to enhance detection of liver carcinoma at magnetic resonance (MR) imaging was studied with in vitro MR spectroscopy and in vivo MR imaging in animal models. After intravenous administration of ferrite, MR spectroscopy showed selective shortening of T2 relaxation times in normal liver but not in tumor. MR imaging showed that ferrite produced profound signal loss only from normal liver and not tumor; thus, differences in signal intensity between liver and tumor were greatly enhanced, especially on pulse sequences with T2-dependent contrast. Motion artifacts were reduced as well because of less signal from liver. Microscopic analysis showed sequestration of ferrite particles in hepatic reticuloendothelial cells but not in hepatocytes or tumor tissue, and there was no evidence of cellular injury. Ferrite particles efficiently and predictably enhance signal differences between normal liver and tumor and permit considerable latitude in selection of pulse sequence and timing parameters. Thus, they have considerable promise as a tissue-specific MR contrast agent for improved detection of liver carcinoma.
通过体外磁共振波谱和动物模型体内磁共振成像，研究了超顺磁性铁氧体颗粒在磁共振（MR）成像中增强肝癌检测的潜力。静脉注射铁氧体后，磁共振波谱显示正常肝脏的T2弛豫时间选择性缩短，而肿瘤组织未出现这种情况。磁共振成像显示，铁氧体仅使正常肝脏产生明显的信号丢失，肿瘤组织则无信号丢失；因此，肝脏与肿瘤之间的信号强度差异显著增强，尤其是在具有T2依赖性对比的脉冲序列上。由于肝脏信号减少，运动伪影也减少了。显微镜分析显示，铁氧体颗粒被肝网状内皮细胞摄取，而肝细胞或肿瘤组织中未摄取，且没有细胞损伤的证据。铁氧体颗粒能有效且可预测地增强正常肝脏与肿瘤之间的信号差异，并在脉冲序列和定时参数的选择上有很大的灵活性。因此，作为一种组织特异性磁共振造影剂，它们在改善肝癌检测方面具有很大的前景。
