School of Biological Science and Engineering, Collaborative Innovation Center for Food Production and Safety, North Minzu University, Yinchuan 750021, People's Republic of China.
Food Funct. 2021 Jan 21;12(2):519-542. doi: 10.1039/d0fo02834g. Epub 2020 Dec 24.
Due to recent lifestyle shifts and health discernments among consumers, synthetic drugs are facing the challenge of controlling disease development and progression. Various medicinal plants and their constituents are recognized for their imminent role in disease management via modulation of biological activities. At present, research scholars have diverted their attention on natural bioactive entities with health-boosting perception to combat the lifestyle-related disarrays. In particular, Zingiber officinale is a medicinal herb that has been commonly used in food and pharmaceutical products. Its detailed chemical composition and high value-added active components have been extensively studied. In this review, we have summarized the pharmacological potential of this well-endowed chemo preventive agent. It was revealed that its functionalities are attributed to several inherent chemical constituents, including 6-gingerol, 8-gingerol, 10-gingerol, 6-shogaol, 6-hydroshogaol, and oleoresin, which were established through many studies (in vitro, in vivo, and cell lines). In this review, we also focused on the therapeutic effects of ginger and its constituents for their effective antioxidant properties. Their consumption may reduce or delay the progression of related diseases, such as cancer, diabetes, and obesity, via modulation of genetic and metabolic activities. The updated data could elucidate the relationship of the extraction processes with the constituents and biological manifestations. We have collated the current knowledge (including the latest clinical data) about the bioactive compounds and bioactivities of ginger. Their detailed mechanisms, which can lay foundation for their food and medical applications are also discussed.
由于最近生活方式的改变和消费者对健康的认识，合成药物在控制疾病发展和进展方面面临挑战。各种药用植物及其成分因其通过调节生物活性在疾病管理中的重要作用而受到认可。目前，研究人员已经将注意力转向具有促进健康认知的天然生物活性实体，以对抗与生活方式相关的失调。特别是姜黄，作为一种药用植物，已广泛应用于食品和药品中。其详细的化学成分和高附加值的活性成分已得到广泛研究。在这篇综述中，我们总结了这种具有丰富化学预防作用的草药的药理学潜力。研究表明，其功能归因于几种固有化学物质，包括 6-姜酚、8-姜酚、10-姜酚、6-姜烯醇、6-羟基姜烯醇和姜油树脂，这些物质已通过许多研究（体外、体内和细胞系）得到证实。在这篇综述中，我们还重点介绍了姜黄及其成分的治疗效果，因为它们具有有效的抗氧化特性。通过调节遗传和代谢活动，它们的摄入可能会减少或延迟相关疾病（如癌症、糖尿病和肥胖症）的进展。最新数据可以阐明提取过程与成分和生物表现之间的关系。我们整理了关于姜黄的生物活性化合物和生物活性的最新知识（包括最新的临床数据）。还讨论了它们的详细机制，为它们在食品和医疗中的应用奠定了基础。
