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造血细胞移植中的端粒长度。

Telomere length in hematopoietic cell transplant.

机构信息

National Cancer Institute.

出版信息

Blood. 2020 Dec 24;136(26):2972-2973. doi: 10.1182/blood.2020008547.

DOI:10.1182/blood.2020008547
PMID:33367550
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7770562/
Abstract

In this issue of , Myllymäki et al evaluated the role of pretransplant leukocyte telomere length (LTL) on survival outcomes in patients with myelodysplastic syndrome (MDS). The authors found associations between recipient short LTL and poor overall survival and high risk of nonrelapse mortality (NRM) after unrelated donor hematopoietic cell transplant (HCT).

摘要

在本期 中，Myllymäki 等人评估了骨髓增生异常综合征（MDS）患者移植前白细胞端粒长度（LTL）对生存结果的作用。作者发现，在无关供体造血细胞移植（HCT）后，受体端粒较短与总生存率差和非复发死亡率（NRM）高相关。

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Telomere length in hematopoietic cell transplant.造血细胞移植中的端粒长度。
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Short telomere length predicts nonrelapse mortality after stem cell transplantation for myelodysplastic syndrome.端粒较短预示骨髓增生异常综合征患者干细胞移植后非复发死亡率。
Blood. 2020 Dec 24;136(26):3070-3081. doi: 10.1182/blood.2020005397.
2
An update on the biology and management of dyskeratosis congenita and related telomere biology disorders.先天性角化不良症及相关端粒生物学疾病的生物学和治疗进展。
Expert Rev Hematol. 2019 Dec;12(12):1037-1052. doi: 10.1080/17474086.2019.1662720. Epub 2019 Sep 10.
3
Pre-transplant short telomeres are associated with high mortality risk after unrelated donor haematopoietic cell transplant for severe aplastic anaemia.移植前短端粒与严重再生障碍性贫血无关供者造血细胞移植后的高死亡风险相关。
Br J Haematol. 2020 Jan;188(2):309-316. doi: 10.1111/bjh.16153. Epub 2019 Aug 19.
4
Telomere Length Calibration from qPCR Measurement: Limitations of Current Method.基于qPCR测量的端粒长度校准：当前方法的局限性
Cells. 2018 Oct 24;7(11):183. doi: 10.3390/cells7110183.
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Relative Telomere Length before Hematopoietic Cell Transplantation and Outcome after Unrelated Donor Hematopoietic Cell Transplantation for Acute Leukemia.急性白血病无关供者造血干细胞移植前的相对端粒长度及移植后的结局
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6
Unraveling secrets of telomeres: one molecule at a time.一次解析一个分子，揭开端粒的秘密。
DNA Repair (Amst). 2014 Aug;20:142-153. doi: 10.1016/j.dnarep.2014.01.012. Epub 2014 Feb 22.
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10
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