Cleft Palate Centre and University Hospital Aarhus and University of Aarhus, Aarhus, Denmark.
Cleft Palate and Craniofacial Center, Department of Plastic Surgery, Helsinki University Hospital, Helsinki, Finland.
Eur J Orthod. 2021 Aug 3;43(4):374-380. doi: 10.1093/ejo/cjaa060.
The Scandcleft trial is a randomized controlled trial that includes children with unilateral cleft lip and palate where registrations are standardized and therefore provides the opportunity to describe craniofacial characteristics in a very large sample of patients.
The aim of this study was to describe craniofacial growth and morphology in a large study sample of 8-year-old children with unilateral cleft lip and palate (UCLP); before orthodontic treatment and before secondary alveolar bone grafting; and to compare the cephalometric values with age-matched non-cleft children from previous growth studies to identify the differences between untreated cleft- and non-cleft children.
There are 429 eight-year-old UCLP patients in the Scandcleft study group. A total of 408 lateral cephalograms with a mean age of 8.1 years were analysed. Cephalometric analyses were performed digitally. The results from three previously published growth studies on non-cleft children were used for comparison.
Cephalometric analyses showed a large variation in craniofacial morphology among the UCLP group. In general, they present with significant maxillary retrusion and reduced intermaxillary relationships compared to the age-matched non-cleft children. In addition, the vertical jaw relationship was decreased, mainly due to decreased maxillary inclination. The upper and lower incisors were retroclined. It can be expected that these differences will increase in significance as the children age.
Results from this study provide proposed norms for the young UCLP before any orthodontic treatment and can be valuable for the clinician in future treatment planning.
ISRCTN29932826.
Scandcleft 试验是一项随机对照试验，纳入了单侧唇腭裂患儿，其注册标准统一，因此有机会对大量患者的头面部特征进行描述。
本研究旨在描述未经正畸治疗和二次牙槽骨植骨前、8 岁单侧唇腭裂（UCLP）患儿的大量研究样本的头面部生长和形态，并与之前生长研究中年龄匹配的非唇腭裂儿童的头影测量值进行比较，以确定未治疗的唇腭裂和非唇腭裂儿童之间的差异。
Scandcleft 研究组共有 429 例 8 岁 UCLP 患儿，共分析了 408 例平均年龄为 8.1 岁的侧位头颅侧位片。头影测量分析采用数字化方法。比较了来自三个之前发表的非唇腭裂儿童生长研究的结果。
头影测量分析显示 UCLP 组患儿的头面部形态存在较大差异。与年龄匹配的非唇腭裂儿童相比，他们普遍存在上颌后缩和上下颌骨关系减小的情况。此外，下颌垂直关系减小，主要是由于上颌骨倾斜度减小所致。上下切牙均为后倾。可以预期，随着儿童年龄的增长，这些差异的显著性会增加。
本研究结果为未经任何正畸治疗的年轻 UCLP 患者提供了建议的正常值，对于临床医生未来的治疗计划具有重要价值。
ISRCTN29932826。
