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脑源性神经营养因子影响肥胖者对食物刺激和食物渴望的神经线索反应。

BDNF influences neural cue-reactivity to food stimuli and food craving in obesity.

机构信息

Department of Addictive Behavior and Addiction Medicine, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, J5, Mannheim, Germany.

Feuerlein Center on Translational Addiction Medicine (FCTS), University of Heidelberg, Heidelberg, Germany.

出版信息

Eur Arch Psychiatry Clin Neurosci. 2021 Aug;271(5):963-974. doi: 10.1007/s00406-020-01224-w. Epub 2020 Dec 26.

DOI:10.1007/s00406-020-01224-w
PMID:33367955
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8236045/
Abstract

There is increasing evidence that brain-derived neurotrophic factor (BDNF) impacts on the development of obesity. We are the first to test the hypothesis that BDNF levels might be associated with neural reactivity to food cues in patients suffering from obesity and healthy controls. We assessed visual food cue-induced neural response in 19 obese patients and 20 matched controls using functional magnetic resonance imaging and analyzed the associations between BDNF levels, food cue-reactivity and food craving. Whole-brain analysis in both groups revealed that food cues elicited higher neural activation in clusters of mesolimbic brain areas including the insula (food > neutral). Patients suffering from obesity showed a significant positive correlation between plasma BDNF levels and visual food cue-reactivity in the bilateral insulae. In addition, patients suffering from obesity with positive food cue-induced insula activation also reported significantly higher food craving than those with low cue-reactivity-an effect that was absent in normal weight participants. The present findings implicate that BDNF levels in patients suffering from obesity might be involved in food craving and obesity in humans. This highlights the importance to consider BDNF pathways when investigating obesity and obesity treatment.

摘要

越来越多的证据表明脑源性神经营养因子（BDNF）会影响肥胖的发展。我们首次检验了这样一个假设，即 BDNF 水平可能与肥胖症患者和健康对照者对食物线索的神经反应有关。我们使用功能磁共振成像评估了 19 名肥胖症患者和 20 名匹配对照者对视觉食物线索的神经反应，并分析了 BDNF 水平、食物线索反应和食物渴求之间的相关性。两组的全脑分析显示，食物线索在包括脑岛在内的中脑边缘区域的簇中引起更高的神经激活（食物>中性）。肥胖症患者的血浆 BDNF 水平与双侧脑岛的视觉食物线索反应呈显著正相关。此外，肥胖症患者中，食物线索诱导的脑岛激活与更高的食物渴求呈正相关，而在体重正常的参与者中则没有这种相关性。本研究结果表明，肥胖症患者的 BDNF 水平可能与人类的食物渴求及肥胖有关。这凸显了在研究肥胖和肥胖治疗时考虑 BDNF 通路的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6569/8236045/dfa365d6c393/406_2020_1224_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6569/8236045/77b2dd2c0926/406_2020_1224_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6569/8236045/dfa365d6c393/406_2020_1224_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6569/8236045/77b2dd2c0926/406_2020_1224_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6569/8236045/dfa365d6c393/406_2020_1224_Fig2_HTML.jpg

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