Beglinger C, Taylor I L, Grossman M I, Solomon T E
Gastroenterology. 1984 Sep;87(3):530-6.
There are apparent similarities in the mechanisms of the intestinal phase of exocrine and pancreatic polypeptide (PP) secretion by the pancreas. To characterize this relationship, we measured incremental responses of protein, bicarbonate, and PP to graded doses of intravenous secretin, caerulein, CCK8, CCK33, bethanechol, and intraduodenally perfused HCl, sodium oleate, and L-phenylalanine in dogs with gastric and pancreatic fistulas and compared them with average postprandial values. Secretin did not release PP at any dose studied, whereas intraduodenal HCl increased PP levels slightly at a load maximal for pancreatic secretion. Caerulein produced dose-related increases in PP secretion (maximal, 106% of meal response) but CCK8 and CCK33 had much less effect at doses equivalent for protein secretion. Bethanechol was a weak stimulant for PP only at the largest tolerable dose. L-Phenylalanine and sodium oleate markedly increased protein secretion, but only oleate clearly stimulated PP. Our results suggest a greater quantitative importance of the intestinal phase for exocrine than endocrine (PP) pancreatic secretion.
胰腺外分泌和胰腺多肽（PP）分泌的肠期机制存在明显相似之处。为了描述这种关系，我们在患有胃瘘和胰腺瘘的犬中，测量了蛋白质、碳酸氢盐和PP对静脉注射不同剂量促胰液素、蛙皮素、CCK8、CCK33、氨甲酰甲胆碱，以及十二指肠灌注盐酸、油酸钠和L-苯丙氨酸的增量反应，并将它们与餐后平均水平进行比较。在所研究的任何剂量下，促胰液素均未释放PP，而十二指肠内盐酸在胰腺分泌的最大负荷时会使PP水平略有升高。蛙皮素使PP分泌呈剂量相关增加（最大为餐后反应的106%），但在蛋白质分泌等效剂量下，CCK8和CCK33的作用要小得多。氨甲酰甲胆碱仅在最大耐受剂量时才是PP的弱刺激剂。L-苯丙氨酸和油酸钠显著增加蛋白质分泌，但只有油酸钠能明显刺激PP。我们的结果表明，肠期对外分泌的定量重要性大于胰腺内分泌（PP）分泌。
