Sakamoto T, Newman J, Fujimura M, Greeley G H, Townsend C M, Thompson J C
Surgery. 1984 Aug;96(2):146-53.
The objective of this study was to examine the effect of neurotensin (NT) on pancreatic exocrine secretion in awake dogs (n = 5) with chronic gastric and pancreatic fistulas. Intravenous (IV) infusion of NT (1 microgram/kg/hr) alone significantly stimulated pancreatic secretion of protein and bicarbonate without causing release of secretin or cholecystokinin-33 (CCK-33). IV NT potentiated the secretory response of pancreatic bicarbonate to the intraduodenal (ID) infusion of HCl alone and to ID infusions of the amino acids, phenylalanine and tryptophan (AA) alone, as well as to an ID mixture of AA plus HCl. IV NT acted in an additive manner with ID AA, ID HCl, or ID AA plus HCl in the stimulation of pancreatic protein output. The addition of IV NT to each luminal secretagogue (ID AA, ID HCl, or ID AA plus HCl) failed to elevate plasma concentrations of CCK-33 or secretin over those observed during ID infusion of each secretagogue alone. ID corn oil (Lipomul) stimulated the simultaneous release of CCK-33, NT, and secretin significantly; IV infusion of NT (0.5 microgram/kg/hr) resulted in plasma NT levels that were similar to levels observed after ID Lipomul. These studies provide evidence that endogenous NT, CCK, and secretin may interact in the physiologic regulation of pancreatic exocrine secretion.
本研究的目的是检测神经降压素（NT）对患有慢性胃瘘和胰瘘的清醒犬（n = 5）胰腺外分泌的影响。单独静脉输注NT（1微克/千克/小时）可显著刺激胰腺蛋白质和碳酸氢盐的分泌，且不会引起促胰液素或胆囊收缩素-33（CCK-33）的释放。静脉注射NT增强了胰腺碳酸氢盐对单独十二指肠内（ID）输注盐酸、单独十二指肠内输注氨基酸苯丙氨酸和色氨酸（AA）以及十二指肠内输注AA加盐酸混合物的分泌反应。静脉注射NT与十二指肠内AA、十二指肠内盐酸或十二指肠内AA加盐酸在刺激胰腺蛋白质分泌方面呈相加作用。在每种腔内促分泌剂（十二指肠内AA、十二指肠内盐酸或十二指肠内AA加盐酸）中添加静脉注射NT后，CCK-33或促胰液素的血浆浓度并未高于单独十二指肠内输注每种促分泌剂时观察到的浓度。十二指肠内玉米油（Lipomul）可显著刺激CCK-33、NT和促胰液素的同时释放；静脉输注NT（0.5微克/千克/小时）导致血浆NT水平与十二指肠内注射Lipomul后观察到的水平相似。这些研究提供了证据，表明内源性NT、CCK和促胰液素可能在胰腺外分泌的生理调节中相互作用。
